{"doi":"10.1007/s10620-025-09072-1","title":"Liver Transplantation and Metabolic Dysfunction Associated Steatotic Liver Disease Is Associated with Markers of Metabolic Risk and Inflammation","abstract":"BACKGROUND: Liver transplant (LT) recipients are at high risk of cardiometabolic disease and mortality. However, routinely employed clinical risk tools have sub-optimal diagnostic performance due to transplant related biological changes. Metabolic vulnerability index (MVX) is a serum-based composite biomarker comprised of nutritional risk [metabolic malnutrition index or MMX] and chronic inflammation [inflammatory vulnerability index or IVX]. MVX is a predictor of cardiovascular risk and all-cause mortality in the general population, however, the effect of LT on MVX is unknown. METHODS: and BMI-matched controls who were propensity matched for BMI. RESULTS: Compared to matched controls, LT recipients had significantly higher MVX (56.9 ± 10.1 vs. 45.8 ± 9.4 vs. 44.8 ± 9.3, p < 0.001), IVX [53.1 ± 12 vs. 39.3 ± 11.2 vs. 40.2 ± 10.9, p < 0.001), and MMX (58.7 ± 8.2 vs. 55.4 ± 6.5 vs. 53.1 ± 6.0, p < 0.001). No significant differences were noted in MVX in LT recipients who developed metabolic dysfunction associated steatotic liver disease (MASLD) after LT. In a multivariate analysis, MVX scores were positively associated with female gender, diabetes, serum AST and BMI, and negatively with dyslipidemia. CONCLUSION: LT is associated with a significant increase in MVX and its components, suggesting a heightened risk in LT recipients that is above that of the non-LT population. Future well designed prospective studies are required to calibrate MVX to clinical outcomes in LT patients.","journal":"Digestive Diseases and Sciences","year":2025,"id":531365,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9599,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1276600,"name":"Madison Nguyen","orcid":"0009-0008-8341-8694","position":1,"is_corresponding":false},{"id":293941,"name":"Margery A. Connelly","orcid":"0000-0002-3917-592X","position":2,"is_corresponding":false},{"id":1277037,"name":"Alok Baral","orcid":null,"position":3,"is_corresponding":false},{"id":889600,"name":"Hiba Khan","orcid":"0000-0002-4877-8028","position":4,"is_corresponding":false},{"id":1277038,"name":"Shreya Garg","orcid":null,"position":5,"is_corresponding":false},{"id":1277040,"name":"Audrey Ang","orcid":null,"position":6,"is_corresponding":false},{"id":1411600,"name":"A Hyeon Kim","orcid":"0000-0003-4825-3456","position":7,"is_corresponding":false},{"id":1277041,"name":"Geneva Roache","orcid":null,"position":8,"is_corresponding":false},{"id":284727,"name":"Kavish R. Patidar","orcid":"0000-0003-3633-382X","position":9,"is_corresponding":false},{"id":1276601,"name":"Idris Yakubu","orcid":"0000-0002-7871-3479","position":10,"is_corresponding":false},{"id":484346,"name":"Irina Shalaurova","orcid":"0000-0003-0191-0383","position":11,"is_corresponding":false},{"id":21853,"name":"Stephan J. L. Bakker","orcid":"0000-0003-3356-6791","position":12,"is_corresponding":false},{"id":293939,"name":"Robin P. F. Dullaart","orcid":"0000-0002-3844-5254","position":13,"is_corresponding":false},{"id":1276602,"name":"Vinay Kumaran","orcid":"0000-0003-0800-6290","position":14,"is_corresponding":false},{"id":950038,"name":"Anh Tuan Bui","orcid":"0000-0003-0397-1307","position":15,"is_corresponding":false},{"id":905003,"name":"Vaishali Patel","orcid":"0000-0002-2890-9457","position":16,"is_corresponding":false},{"id":325241,"name":"Mohammad Shadab Siddiqui","orcid":"0000-0001-7392-7489","position":17,"is_corresponding":false},{"id":1277039,"name":"Rehan Razzaq","orcid":null,"position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:51:14.579161Z","pmid":"40274677","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}