{"doi":"10.1007/s10620-022-07562-0","title":"Crohn’s Disease Is Associated with Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease","abstract":null,"journal":"Digestive Diseases and Sciences","year":2023,"id":637351,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1260888,"name":"Rajat Garg","orcid":"0000-0001-8713-0198","position":1,"is_corresponding":false},{"id":1654809,"name":"Gopanandan Parthasarthy","orcid":null,"position":2,"is_corresponding":false},{"id":336841,"name":"Amy S. Nowacki","orcid":"0000-0002-1216-1448","position":3,"is_corresponding":false},{"id":1583445,"name":"Ruthvik Padival","orcid":null,"position":4,"is_corresponding":false},{"id":1654810,"name":"Arthur McCullough","orcid":null,"position":5,"is_corresponding":false},{"id":460566,"name":"Taha Qazi","orcid":"0000-0001-6770-9055","position":6,"is_corresponding":false},{"id":671191,"name":"Benjamin Click","orcid":"0000-0001-9048-7972","position":7,"is_corresponding":false},{"id":294494,"name":"Florian Rieder","orcid":"0000-0002-9087-1568","position":8,"is_corresponding":false},{"id":279966,"name":"Benjamin L. Cohen","orcid":null,"position":9,"is_corresponding":false},{"id":1141477,"name":"Manik Aggarwal","orcid":"0000-0002-6087-1700","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Crohn’s Disease Is Associated with Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease","abstract":"<h4>Background</h4>Chronic inflammation in IBD is postulated to drive NAFLD progression from steatosis to fibrosis.<h4>Aims</h4>To study the histopathological spectrum of NAFLD in Crohn disease (CD) and Ulcerative colitis (UC).<h4>Methods</h4>Patients with biopsy proven NAFLD at a quaternary center from 2008 to 2018 were included in this retrospective analysis. Inflammatory bowel disease (IBD) diagnosed either clinically and/or endoscopically at the time of liver biopsy. Multivariable regression and propensity score (PS) weighted analysis were conducted. Statistical analysis were performed using SAS statistical software.<h4>Results</h4>Among 1009 patients with NAFLD a diagnosis of IBD was identified in 50 cases (34 CD and 16 UC). On multivariable analysis; CD was independently associated with significantly higher odds of advanced fibrosis (AF) on liver biopsy (adjusted OR = 4.09, 95% CI = 1.40-11.94) compared to NAFLD patients without IBD. Similar results were obtained with both the overlap PS weighted model (OR = 3.17, 95% CI = 1.55-6.49) and the PS matched model (OR = 3.49, 95% CI = 1.50-8.13).<h4>Conclusion</h4>In a large cohort of patients with histologically well characterized NAFLD, AF was more common in CD patients than NAFLD patients without IBD. These findings must be confirmed in a larger cohort, but suggest CD patients with NAFLD could be at greater risk for liver fibrosis.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35731428","pmcid":"PMC10022843","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK123233","title":null}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10022843/pdf/nihms-1877134.pdf","host_type":"repository"},{"url":"https://link.springer.com/content/pdf/10.1007/s10620-022-07562-0.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s10620-022-07562-0/fulltext.html","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Liver","Humans","Colitis, Ulcerative","Inflammatory Bowel Diseases","Crohn Disease","Liver Cirrhosis","Biopsy","Risk Factors","Retrospective Studies","Non-alcoholic Fatty Liver Disease"],"keywords":["fibrosis","Inflammatory Bowel Disease","NASH","Nafld"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T18:48:04.872882Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}