{"doi":"10.1007/s10585-013-9610-9","title":"Pre-treatment of mice with tumor-conditioned media accelerates metastasis to lymph nodes and lungs: a new spontaneous breast cancer metastasis model","abstract":null,"journal":"Clinical & Experimental Metastasis","year":2014,"id":605257,"datarank":0.5416376868966337,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"self_citation_contribution":0.5416376868966337,"citation_network_contribution":0.0,"self_endowment_contribution":0.5416376868966337,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":369313,"name":"Niranjan B. Pandey","orcid":"0000-0003-3652-0289","position":1,"is_corresponding":false},{"id":299224,"name":"Aleksander S. Popel","orcid":"0000-0002-6706-9235","position":2,"is_corresponding":false},{"id":796141,"name":"Esak Lee","orcid":"0000-0002-5328-6677","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Pre-treatment of mice with tumor-conditioned media accelerates metastasis to lymph nodes and lungs: a new spontaneous breast cancer metastasis model","abstract":"Current spontaneous metastasis models require a long period of observation after establishment of primary tumors to see significant metastatic progression. The degree of metastasis is not consistent among animals: this is problematic since it requires the use of a large number of animals to obtain reliable statistics. Here we report that pre-treatment of animals with tumor-conditioned media (TCM) consistently accelerates spontaneous metastasis in breast cancer. An inguinal breast tumor model facilitated by TCM showed robust anterior metastasis to the axillary and brachial lymph nodes (LN), and the lungs compared to the serum-free media treated group. The LN in TCM-treated animals showed enhanced angiogenesis and lymphangiogenesis. Primary tumors and lungs in TCM-treated animals showed enhanced lymphangiogenesis with no significant change in angiogenesis. TCM-treated animals also showed metastatic dissemination to abdomen from the primary injection site: this would generally enhance metastasis to other organs. In sum, the addition of TCM pre-treatment to current metastasis models results in accelerated and robust metastasis which would enable more efficient evaluation of anti-metastatic agents.","is_dataset_classified":null,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23963763","pmcid":"PMC3947147","openalex_id":"https://openalex.org/W2091004743","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"R01 CA138264","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01CA138264-13","title":"Predictive experiment-based multiscale models of the tumor immune microenvironment and immunotherapy in breast cancer"}],"total_grants":2,"fwci":1.8788,"citation_percentile":0.85887821,"influential_citations":0,"citation_trend":[{"year":2014,"count":3},{"year":2015,"count":5},{"year":2016,"count":5},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":3},{"year":2020,"count":5},{"year":2021,"count":3},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"green","license":"Springer TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3947147","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3947147","host_type":"repository"},{"url":"http://link.springer.com/content/pdf/10.1007/s10585-013-9610-9.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s10585-013-9610-9/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s10585-013-9610-9","host_type":"publisher"},{"url":"https://doi.org/10.1007/s10585-013-9610-9","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23963763","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc3947147?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.1007/s10585-013-9610-9","host_type":""}],"fields_of_study":["Lymphatic System and Diseases","Cancer Cells and Metastasis","Cancer Research and Treatments","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Animals","Disease Models, Animal","Fluorescent Antibody Technique","Humans","Immunohistochemistry","Lung Neoplasms","Lymphatic Metastasis","Mammary Neoplasms, Experimental","Culture Media, Conditioned","Cell Line, Tumor","Mice"],"keywords":["Metastasis","Lymphangiogenesis","Medicine","Lymph","Primary tumor","Angiogenesis","Breast cancer","Cancer","Surgical oncology","Metastatic breast cancer","Axillary lymph nodes","Oncology","Internal medicine","Pathology","Cancer research","Lung Neoplasms","Fluorescent Antibody Technique","Mammary Neoplasms, Experimental","Immunohistochemistry","Disease Models, Animal","Mice","Cell Line, Tumor","Culture Media, Conditioned","Lymphatic Metastasis","Animals","Humans"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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