{"doi":"10.1007/s10577-020-09641-2","title":"Using telomeric chromosomal aberrations to evaluate clastogen-induced genomic instability in mammalian cells","abstract":null,"journal":"Chromosome Research","year":2020,"id":638550,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1658607,"name":"Alejandro D. Bolzán","orcid":"0000-0002-3627-1182","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Using telomeric chromosomal aberrations to evaluate clastogen-induced genomic instability in mammalian cells","abstract":"Telomeres, the specialized nucleoproteic complexes localized at the physical ends of linear eukaryotic chromosomes, play a fundamental role in maintaining chromosomal stability and integrity, being one of the leading guardians of genome stability. In recent years, the identification and analysis of chromosomal aberrations involving telomeres has proven to be a unique tool to evaluate misrepaired and unrepaired chromosome damage in mammalian cells. Telomere instability constitutes an important source of genomic instability, a phenomenon characteristic of cancer cells, and also common in cells exposed to chemical or physical mutagens which induce chromosomal aberrations by producing chromosome breakage (clastogens). In the present review, we will focus on the chromosomal aberrations involving telomeres and their importance to determine the clastogen-induced genomic instability present in mammalian cells.","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32940874","pmcid":null,"openalex_id":"https://openalex.org/W3087678180","authors":[],"funders":[{"funder_name":"CONICET","grant_id":"PIP No. 0182","title":null},{"funder_name":"Comisión de Investigaciones Científicas","grant_id":"","title":null},{"funder_name":"Universidad Nacional de La Plata","grant_id":"","title":null}],"total_grants":3,"fwci":1.1299,"citation_percentile":0.77404111,"influential_citations":0,"citation_trend":[{"year":2020,"count":2},{"year":2021,"count":5},{"year":2022,"count":3},{"year":2024,"count":5},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"green","license":"cc-by-nc-sa","oa_locations":[{"url":"http://hdl.handle.net/11336/154072","host_type":"repository"},{"url":"http://hdl.handle.net/11336/154072","host_type":"repository"},{"url":"https://link.springer.com/content/pdf/10.1007/s10577-020-09641-2.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s10577-020-09641-2/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s10577-020-09641-2","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32940874","host_type":"repository"}],"fields_of_study":["Telomeres, Telomerase, and Senescence","DNA Repair Mechanisms","Carcinogens and Genotoxicity Assessment","Animals","Chromosomal Instability","Chromosome Aberrations","Genomic Instability","Humans","Mammals","Mutagens","Organ Specificity","Risk Factors","Telomere"],"mesh_terms":["Animals","Chromosome Aberrations","Humans","Mammals","Mutagens","Organ Specificity","Risk Factors","Telomere","Genomic Instability","Chromosomal Instability"],"keywords":["Telomere","Genome instability","Chromosome instability","Biology","Clastogen","Chromosome","Genetics","Chromosomal fragile site","Chromosome engineering","Chromothripsis","Cell biology","DNA","DNA damage","Gene","Genotoxicity","Chromosomal Instability","Chromosome Damage","Telomere Dysfunction","Telomere Instability","Telomere Attrition"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Climate action"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T20:52:42.830748Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}