{"doi":"10.1007/s10554-022-02722-9","title":"Validation of a semi-automatic software for optical coherence tomography – analysis in heart transplanted patients","abstract":"Optical Coherence Tomography (OCT) is an intravascular imaging modality enabling detailed evaluation of cardiac allograft vasculopathy (CAV) after heart transplantation (HTx). However, its clinical application remains hampered by time-consuming manual quantitative analysis. We aimed to validate a semi-automated quantitative OCT analysis software (Iowa Coronary Wall Analyzer, ICWA-OCT) to improve OCT-analysis in HTx patients. 23 patients underwent OCT evaluation of all three major coronary arteries at 3 months (3M) and 12 months (12M) after HTx. We analyzed OCT recordings using the semiautomatic software and compared results with measurements from a validated manual software. For semi-automated analysis, 31,228 frames from 114 vessels were available. The validation was based on a subset of 4287 matched frames. We applied mixed model statistics to accommodate the multilevel data structure with method as a fixed effect. Lumen (minimum, mean, maximum) and media (mean, maximum) metrics showed no significant differences. Mean and maximum intima area were underestimated by the semi-automated method (β-methodmean = − 0.289 mm2, p < 0.01; β-methodmax = − 0.695 mm2, p < 0.01). Bland–Altman analyses showed increasing semi-automatic underestimation of intima measurements with increasing intimal extent. Comparing 3M to 12M progression between methods, mean intimal area showed minor underestimation (β-methodmean = − 1.03 mm2, p = 0.04). Lumen and media metrics showed excellent agreement between the manual and semi-automated method. Intima metrics and progressions from 3M to 12M were slightly underestimated by the semi-automated OCT software with unknown clinical relevance. The semi-automated software has the future potential to provide robust and time-saving evaluation of CAV progression.","journal":"The International Journal of Cardiovascular Imaging","year":2022,"id":283984,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":523691,"name":"Zhi Chen","orcid":"0000-0002-2725-6239","position":1,"is_corresponding":false},{"id":961252,"name":"Tor Skibsted Clemmensen","orcid":"0000-0002-6042-6404","position":2,"is_corresponding":false},{"id":961253,"name":"Omeed Neghabat","orcid":"0000-0002-5889-0953","position":3,"is_corresponding":false},{"id":961254,"name":"Emil Nielsen Holck","orcid":"0009-0009-6697-1073","position":4,"is_corresponding":false},{"id":523689,"name":"Michal Pazderník","orcid":"0000-0001-7486-7705","position":5,"is_corresponding":false},{"id":961763,"name":"Lone Juul Hune Mogensen","orcid":null,"position":6,"is_corresponding":false},{"id":796509,"name":"Andreas Wahle","orcid":null,"position":7,"is_corresponding":false},{"id":14561,"name":"Milan Sonka","orcid":"0000-0002-9613-9968","position":8,"is_corresponding":false},{"id":961255,"name":"Hans Eiskjær","orcid":"0000-0003-1520-1924","position":9,"is_corresponding":false},{"id":961251,"name":"Niels Møller Jensen","orcid":"0000-0002-5009-5955","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:29:32.702533Z","pmid":"36109445","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}