{"doi":"10.1007/s10461-021-03169-0","title":"Modeling Adherence Interventions Among Youth with HIV in the United States: Clinical and Economic Projections","abstract":"The Adolescent Medicine Trials Network for HIV/AIDS Interventions is evaluating treatment adherence interventions (AI) to improve virologic suppression (VS) among youth with HIV (YWH). Using a microsimulation model, we compared two strategies: standard-of-care (SOC) and a hypothetical 12-month AI that increased cohort-level VS in YWH in care by an absolute ten percentage points and cost $100/month/person. Projected outcomes included primary HIV transmissions, deaths and life-expectancy, lifetime HIV-related costs, and incremental cost-effectiveness ratios (ICERs, $/quality-adjusted life-year [QALY]). Compared to SOC, AI would reduce HIV transmissions by 15% and deaths by 12% at 12 months. AI would improve discounted life expectancy/person by 8 months at an added lifetime cost/person of $5,300, resulting in an ICER of $7,900/QALY. AI would be cost-effective at $2,000/month/person or with efficacies as low as a 1 percentage point increase in VS. YWH-targeted adherence interventions with even modest efficacy could improve life expectancy, prevent onward HIV transmissions, and be cost-effective.","journal":"AIDS and Behavior","year":2021,"id":198216,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9464,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":273905,"name":"Audrey C. Bangs","orcid":"0000-0002-7283-7200","position":1,"is_corresponding":false},{"id":130929,"name":"Michael G. Hudgens","orcid":"0000-0002-9106-4194","position":2,"is_corresponding":false},{"id":382511,"name":"Kunjal Patel","orcid":"0000-0003-0002-681X","position":3,"is_corresponding":false},{"id":385745,"name":"Allison L. Agwu","orcid":"0000-0002-8449-222X","position":4,"is_corresponding":false},{"id":263592,"name":"Ingrid V. Bassett","orcid":"0000-0001-6920-6080","position":5,"is_corresponding":false},{"id":614922,"name":"Aditya H. Gaur","orcid":"0000-0002-6639-5231","position":6,"is_corresponding":false},{"id":273590,"name":"Emily P. Hyle","orcid":"0000-0001-8721-106X","position":7,"is_corresponding":false},{"id":426167,"name":"Catherine M. Crespi","orcid":"0000-0002-6150-2181","position":8,"is_corresponding":false},{"id":413427,"name":"Keith J. Horvath","orcid":"0000-0001-7569-2839","position":9,"is_corresponding":false},{"id":437796,"name":"Caitlin M. Dugdale","orcid":"0000-0002-6604-6111","position":10,"is_corresponding":false},{"id":423768,"name":"Kimberly A. Powers","orcid":"0000-0001-7980-9846","position":11,"is_corresponding":false},{"id":260411,"name":"H. Jonathon Rendina","orcid":"0000-0002-0148-2852","position":12,"is_corresponding":false},{"id":276220,"name":"Milton C. Weinstein","orcid":null,"position":13,"is_corresponding":false},{"id":226457,"name":"Rochelle P. Walensky","orcid":"0000-0002-8795-379X","position":14,"is_corresponding":false},{"id":273595,"name":"Kenneth A. Freedberg","orcid":"0000-0001-6471-7930","position":15,"is_corresponding":false},{"id":273593,"name":"Andrea Ciaranello","orcid":"0000-0002-4268-3263","position":16,"is_corresponding":false},{"id":273591,"name":"Anne M. Neilan","orcid":"0000-0001-7915-4974","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-18T23:50:27.616568Z","pmid":"33547993","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}