{"doi":"10.1007/s10334-025-01304-9","title":"Exercise MRI stress testing of the human heart at 3 Tesla: measurement precision of biventricular function and aortic blood flow during steady-state bicycling exercise","abstract":"OBJECTIVE: This work aimed to demonstrate the feasibility of quantifying heart function during bicycling exercise with dynamic real-time cine MRI at 3 Tesla, and to assess its measurement precision. MATERIALS AND METHODS: Twelve volunteers performed steady-state bicycling exercise, while real-time cine MR images were collected using a 72-channel receiver coil array and a parallel imaging acceleration factor of 5. Biventricular end-diastolic and end-systolic (ESV) volumes and function during exercise were compared with resting-state real-time cine MRI and conventional cardiac-gated cine MRI under breath holding, and validated against 2D phase-contrast MRI-based estimates of aortic blood flow. Precision was evaluated as the inter-session measurement repeatability. RESULTS: Left (LV) and right ventricular (RV) stroke volumes (SV) increased progressively with exercise intensity, which was mediated by a decrease in ESV. Likewise, LV SV estimated with 2D phase-contrast MRI increased from 90 ± 17 mL at rest to 114 ± 29 mL during vigorous-intensity exercise. Repeatability coefficients were 52% and 41% for LV SV at moderate- and vigorous-intensity exercise, while RV SV repeatability coefficients were 58% and 42%, respectively. DISCUSSION: We established an exercise MRI stress testing protocol for quantifying biventricular volumes and function during moderate- and vigorous-intensity steady-state bicycling exercise.","journal":"Magnetic Resonance Materials in Physics Biology and Medicine","year":2025,"id":584131,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8415,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1497019,"name":"Martijn Froeling","orcid":"0000-0003-3841-0497","position":1,"is_corresponding":false},{"id":528776,"name":"Tim Leiner","orcid":"0000-0003-1885-5499","position":2,"is_corresponding":false},{"id":339866,"name":"Hildo J. Lamb","orcid":"0000-0002-6969-2418","position":3,"is_corresponding":false},{"id":289148,"name":"S. Matthijs Boekholdt","orcid":"0000-0002-0861-0765","position":4,"is_corresponding":false},{"id":1286621,"name":"H T Jørstad","orcid":"0000-0003-3617-3256","position":5,"is_corresponding":false},{"id":343770,"name":"Gustav J. Strijkers","orcid":"0000-0001-6700-5058","position":6,"is_corresponding":false},{"id":748562,"name":"Adrianus J. Bakermans","orcid":"0000-0001-9291-9441","position":7,"is_corresponding":false},{"id":1497018,"name":"Hugo Klarenberg","orcid":"0000-0002-1477-3675","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:59:11.978098Z","pmid":"41342970","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}