{"doi":"10.1007/s10237-018-1012-0","title":"Probing the biophysical properties of tumor cells during mitosis by atomic force microscopy","abstract":null,"journal":"Biomechanics and Modeling in Mechanobiology","year":2018,"id":678285,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1772223,"name":"Minghai You","orcid":null,"position":1,"is_corresponding":false},{"id":515139,"name":"Yuhua Wang","orcid":"0000-0003-3138-1312","position":2,"is_corresponding":false},{"id":1772225,"name":"Yide Huang","orcid":null,"position":3,"is_corresponding":false},{"id":1658545,"name":"Shusen Xie","orcid":null,"position":4,"is_corresponding":false},{"id":510285,"name":"Yao Lin","orcid":"0000-0001-5227-2663","position":5,"is_corresponding":false},{"id":1352719,"name":"Hongqin Yang","orcid":"0000-0002-7794-5921","position":6,"is_corresponding":false},{"id":1772220,"name":"Ningcheng Jiang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Probing the biophysical properties of tumor cells during mitosis by atomic force microscopy","abstract":"Mitosis is an important physiological event accompanying with dramatic changes of cellar biophysical properties. Failure of mitosis results in cell death or chromosome aneuploidy. In this study, we used atomic force microscopy to probe and compare the biophysical properties of tumor cells at different stages during mitosis. The rounding forces of MCF-7 cells oscillated during mitosis. At anaphase, the average elasticity of cells was higher than that at other phases. Cholesterol depletion with M[Formula: see text]CD led to an increase in the average elasticity, whereas the average roughness of membrane surface decreased at the absence of cholesterol. Our study indicated that the distribution of actin filaments could affect the biophysical properties of tumor cells and cellular morphology during mitosis. Furthermore, the biophysical properties of tumor cells were also regulated by membrane cholesterol during mitosis. This work provides a new detection approach for monitoring tumor cell development at single cell level.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29550968","pmcid":null,"openalex_id":"https://openalex.org/W2792084677","authors":[],"funders":[{"funder_name":"Ministry of Science and Technology of the People’s Republic of China","grant_id":"2015CB352006","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"61335011","title":null}],"total_grants":2,"fwci":0.2577,"citation_percentile":0.51656464,"influential_citations":0,"citation_trend":[{"year":2019,"count":1},{"year":2020,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/article/10.1007/s10237-018-1012-0/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s10237-018-1012-0.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1007/s10237-018-1012-0","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29550968","host_type":"repository"}],"fields_of_study":["Force Microscopy Techniques and Applications","Cellular Mechanics and Interactions","Lipid Membrane Structure and Behavior"],"mesh_terms":["Cholesterol","Elasticity","Humans","Mitosis","Neoplasms","Microscopy, Atomic Force","Cell Line, Tumor","Cell Shape","Biophysical Phenomena","MCF-7 Cells"],"keywords":["Mitosis","Anaphase","Binucleated cells","Cell biology","Biophysics","Atomic force microscopy","Cell","Interphase","Materials science","Chemistry","Biology","Cell cycle","Nanotechnology","Biochemistry","Tumor cells","Biophysical Properties"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T05:12:32.709011Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}