{"doi":"10.1007/s10120-024-01499-1","title":"Family history and gastric cancer incidence and mortality in Asia: a pooled analysis of more than half a million participants","abstract":"BACKGROUND: The family history of gastric cancer holds important implications for cancer surveillance and prevention, yet existing evidence predominantly comes from case-control studies. We aimed to investigate the association between family history of gastric cancer and gastric cancer risk overall and by various subtypes in Asians in a prospective study. METHODS: We included 12 prospective cohorts with 550,508 participants in the Asia Cohort Consortium. Cox proportional hazard regression was used to estimate study-specific adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between family history of gastric cancer and gastric cancer incidence and mortality, then pooled using random-effects meta-analyses. Stratified analyses were performed for the anatomical subsites and histological subtypes. RESULTS: During the mean follow-up of 15.6 years, 2258 incident gastric cancers and 5194 gastric cancer deaths occurred. The risk of incident gastric cancer was higher in individuals with a family history of gastric cancer (HR 1.44, 95% CI 1.32-1.58), similarly in males (1.44, 1.31-1.59) and females (1.45, 1.23-1.70). Family history of gastric cancer was associated with both cardia (HR 1.26, 95% CI 1.00-1.60) and non-cardia subsites (1.49, 1.35-1.65), and with intestinal- (1.48, 1.30-1.70) and diffuse-type (1.59, 1.35-1.87) gastric cancer incidence. Positive associations were also found for gastric cancer mortality (HR 1.30, 95% CI 1.19-1.41). CONCLUSIONS: In this largest prospective study to date on family history and gastric cancer, a familial background of gastric cancer increased the risk of gastric cancer in the Asian population. Targeted education, screening, and intervention in these high-risk groups may reduce the burden of gastric cancer.","journal":"Gastric Cancer","year":2024,"id":431073,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5906,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":429036,"name":"Minkyo Song","orcid":"0000-0002-9412-2871","position":1,"is_corresponding":false},{"id":360916,"name":"Sarah Krull Abe","orcid":"0000-0003-3991-2739","position":2,"is_corresponding":false},{"id":360917,"name":"Md. Shafiur Rahman","orcid":"0000-0003-1911-6807","position":3,"is_corresponding":false},{"id":636323,"name":"Md. Rashedul Islam","orcid":"0000-0003-3568-0870","position":4,"is_corresponding":false},{"id":360921,"name":"Eiko Saito","orcid":"0000-0002-4550-9631","position":5,"is_corresponding":false},{"id":1234873,"name":"Katherine De la Torre","orcid":"0000-0003-2654-0171","position":6,"is_corresponding":false},{"id":31512,"name":"Norie Sawada","orcid":"0000-0002-9936-1476","position":7,"is_corresponding":false},{"id":727648,"name":"Akiko Tamakoshi","orcid":"0000-0002-9761-3879","position":8,"is_corresponding":false},{"id":240065,"name":"Xiao‐Ou Shu","orcid":"0000-0002-0711-8314","position":9,"is_corresponding":false},{"id":451071,"name":"Hui Cai","orcid":"0000-0002-6182-966X","position":10,"is_corresponding":false},{"id":81040,"name":"Atsushi Hozawa","orcid":"0000-0002-8031-8523","position":11,"is_corresponding":false},{"id":360910,"name":"Seiki Kanemura","orcid":"0000-0003-0454-0322","position":12,"is_corresponding":false},{"id":38823,"name":"Jeongseon Kim","orcid":"0000-0002-0889-2686","position":13,"is_corresponding":false},{"id":302468,"name":"Yu Chen","orcid":"0000-0002-1519-4894","position":14,"is_corresponding":false},{"id":259996,"name":"Hidemi Ito","orcid":"0000-0002-8023-4581","position":15,"is_corresponding":false},{"id":360911,"name":"Yumi Sugawara","orcid":"0000-0002-0197-6772","position":16,"is_corresponding":false},{"id":259990,"name":"Sue K. 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