{"doi":"10.1007/s10120-021-01229-x","title":"Synergistic effects of Rapamycin and Fluorouracil to treat a gastric tumor in a PTEN conditional deletion mouse model","abstract":null,"journal":"Gastric Cancer","year":2022,"id":602391,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1544896,"name":"Shuang-qing Peng","orcid":null,"position":1,"is_corresponding":false},{"id":1544898,"name":"Li-li Cui","orcid":null,"position":2,"is_corresponding":false},{"id":1544899,"name":"Wanying Cao","orcid":null,"position":3,"is_corresponding":false},{"id":1544901,"name":"Li-shi Zhang","orcid":null,"position":4,"is_corresponding":false},{"id":1544903,"name":"Zeng-ming Zhao","orcid":null,"position":5,"is_corresponding":false},{"id":1357129,"name":"Li Jia","orcid":"0000-0002-5566-9209","position":6,"is_corresponding":false},{"id":1544904,"name":"Ting-fen Zhang","orcid":null,"position":7,"is_corresponding":false},{"id":1544905,"name":"Jia-bin Guo","orcid":null,"position":8,"is_corresponding":false},{"id":1544906,"name":"Chengfang Pang","orcid":"0000-0002-6332-8148","position":9,"is_corresponding":false},{"id":1544894,"name":"Cong-hui Zhu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Synergistic effects of Rapamycin and Fluorouracil to treat a gastric tumor in a PTEN conditional deletion mouse model","abstract":"The tumor suppressor gene phosphatase and tensin homolog (PTEN) in PI3K/Akt/mTOR pathway is essential in inhibiting tumor growth and metastasis. However, whether the mutation of PTEN gene could induce tumorigenesis and impact the treatment of gastric cancer is still unclear. The purpose of the study was to investigate the combined treatment of gastric tumorigenesis using Rapamycin and Fluorouracil (5-Fu) through interfering with the Akt/mTOR pathway in a mouse model with PTEN conditional deletion. Three groups of mice were exposed for 5 days to Rapamycin and 5-Fu separately and together. The gene expression of the Akt/mTOR pathway, the protein expression of caspase-3 and p-Akt, p-S6K and p-4EBP1, and the pathological changes in stomachs were analyzed. Our study demonstrates that the conditional PTEN deletion in the cells of glandular stomach induces hyperplastic gastric tumors in mice. The combined Rapamycin administration with 5-Fu resulted in better outcomes than their separate administration for the treatment of gastric cancer by inhibiting the mTOR signal pathway. Our study indicates that Rapamycin has a synergistic interaction with chemotherapeutic 5-Fu, and demonstrates a potential therapeutic combination treatment on glandular stomach tumor with PTEN functional absence or aberrantly activated Akt/mTOR pathway. It provides important insights into the inhibition of the Akt/mTOR pathway in gastric cancer clinical therapy.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34370147","pmcid":null,"openalex_id":"https://openalex.org/W3192317526","authors":[],"funders":[{"funder_name":"National Basic Research Program of China","grant_id":"2009ZX09501-027","title":null},{"funder_name":"National Basic Research Program of China","grant_id":"2009ZX09501-034","title":null},{"funder_name":"Villum Fonden","grant_id":"00028340","title":null},{"funder_name":"Villum Fonden","grant_id":"","title":null}],"total_grants":4,"fwci":0.3702,"citation_percentile":0.55449003,"influential_citations":0,"citation_trend":[{"year":2022,"count":2},{"year":2023,"count":3},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s10120-021-01229-x.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s10120-021-01229-x.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s10120-021-01229-x/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s10120-021-01229-x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34370147","host_type":"repository"},{"url":"https://orbit.dtu.dk/en/publications/45c17eb9-83d3-4bf0-93a1-6942c2670fa8","host_type":"repository"}],"fields_of_study":["PI3K/AKT/mTOR signaling in cancer","Cancer Mechanisms and Therapy","Polyamine Metabolism and Applications"],"mesh_terms":["Animals","Fluorouracil","Humans","Stomach Neoplasms","Phosphatidylinositol 3-Kinases","Sirolimus","Cell Line, Tumor","Proto-Oncogene Proteins c-akt","PTEN Phosphohydrolase","Mice"],"keywords":["PTEN","PI3K/AKT/mTOR pathway","Tensin","Cancer research","Protein kinase B","Carcinogenesis","RPTOR","Cancer","Sirolimus","Tumor suppressor gene","Medicine","Biology","Signal transduction","Internal medicine","Cell biology","5-fluorouracil","Rapamycin","Akt/mtor","Gastric Tumorigenesis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T19:14:27.340504Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}