{"doi":"10.1007/s10096-022-04523-3","title":"Successful treatment of ceftazidime/avibactam combined with aztreonam in the NDM-producing Klebsiella pneumoniae bloodstream and intestinal infections in a NK/T lymphoma patient with agranulocytosis during autologous hematopoietic stem cell transplantation: a case report","abstract":"<jats:title>Abstract </jats:title><jats:p>New Delhi metallo-beta-lactamase (NDM)-producing Klebsiella pneumoniae is increasingly reported worldwide. Clinicians face significant challenges in the treatment of this multidrug-resistant bacterium. The combination of ceftazidime/avibactam (CAZ/AVI) and aztreonam (ATM) is currently probably the most effective strategy for the treatment of such infection. We described a patient diagnosed with NK/T cell lymphoma who underwent autologous hematopoietic stem cell transplantation (ASCT) in the hematology department. The patient developed severe infection after ASCT. Blood and stool cultures showed carbapenem-resistant <jats:italic>K. pneumoniae</jats:italic>. Blood sample was detected as NDM-producing <jats:italic>K. pneumoniae</jats:italic>. We successfully treated this infection with CAZ/AVI and ATM.</jats:p>","journal":"European Journal of Clinical Microbiology &amp; Infectious Diseases","year":2022,"id":633325,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1641928,"name":"Qingqing Lin","orcid":null,"position":1,"is_corresponding":false},{"id":1641929,"name":"Lizhi Ouyang","orcid":null,"position":2,"is_corresponding":false},{"id":1035976,"name":"Chengjie Zhou","orcid":"0000-0003-3729-0649","position":3,"is_corresponding":false},{"id":1641930,"name":"Huajun Wang","orcid":null,"position":4,"is_corresponding":false},{"id":1153552,"name":"Shiyi Liu","orcid":"0000-0002-5653-4955","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Successful treatment of ceftazidime/avibactam combined with aztreonam in the NDM-producing Klebsiella pneumoniae bloodstream and intestinal infections in a NK/T lymphoma patient with agranulocytosis during autologous hematopoietic stem cell transplantation: a case report","abstract":"<jats:title>Abstract </jats:title><jats:p>New Delhi metallo-beta-lactamase (NDM)-producing Klebsiella pneumoniae is increasingly reported worldwide. Clinicians face significant challenges in the treatment of this multidrug-resistant bacterium. The combination of ceftazidime/avibactam (CAZ/AVI) and aztreonam (ATM) is currently probably the most effective strategy for the treatment of such infection. We described a patient diagnosed with NK/T cell lymphoma who underwent autologous hematopoietic stem cell transplantation (ASCT) in the hematology department. The patient developed severe infection after ASCT. Blood and stool cultures showed carbapenem-resistant <jats:italic>K. pneumoniae</jats:italic>. Blood sample was detected as NDM-producing <jats:italic>K. pneumoniae</jats:italic>. We successfully treated this infection with CAZ/AVI and ATM.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36371600","pmcid":"PMC9660021","openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s10096-022-04523-3.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s10096-022-04523-3/fulltext.html","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9660021","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9660021","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9660021?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":[],"keywords":["Carbapenem-resistant Klebsiella Pneumoniae","New Delhi Metallo-beta-lactamase","Ceftazidime/avibactam Aztreonam"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T11:50:38.505039Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}