{"doi":"10.1007/s10096-017-3012-x","title":"Dissemination of bla OXA-370 gene among several Enterobacteriaceae species in Brazil","abstract":null,"journal":"European Journal of Clinical Microbiology &amp; Infectious Diseases","year":2017,"id":686712,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1794004,"name":"F. P. Rozales","orcid":null,"position":1,"is_corresponding":false},{"id":1794006,"name":"L. Antochevis","orcid":null,"position":2,"is_corresponding":false},{"id":1794008,"name":"L. S. Nunes","orcid":null,"position":3,"is_corresponding":false},{"id":1794009,"name":"A. S. Martins","orcid":null,"position":4,"is_corresponding":false},{"id":1794010,"name":"A. L. Barth","orcid":null,"position":5,"is_corresponding":false},{"id":1794011,"name":"J. M. Sampaio","orcid":null,"position":6,"is_corresponding":false},{"id":1794012,"name":"A. P. Zavascki","orcid":null,"position":7,"is_corresponding":false},{"id":1794003,"name":"C. M. Magagnin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Dissemination of bla OXA-370 gene among several Enterobacteriaceae species in Brazil","abstract":"OXA-370 is a recently described OXA-48 variant that has only been described in a few Enterobacter spp. and Klebsiella pneumoniae isolates. The purpose of this study is to assess the prevalence of OXA-370-producing isolates in carbapenem-nonsusceptible Enterobacteriaceae recovered from 28 hospitals from Brazil. Real-time PCR was used to determine the presence of bla <sub>NDM-1</sub>, bla <sub>KPC-2</sub>, bla <sub>VIM-type</sub>, bla <sub>GES-type</sub>, bla <sub>OXA-48-like</sub>, and bla <sub>IMP-type</sub> genes. A total of 4,451 Enterobacteriaceae were screened. The gene bla <sub>OXA-48-like</sub> was detected in 74 (2.5%) isolates, mostly of Enterobacter spp. (44.6% E. cloacae and 2.7% E. aerogenes) and Klebsiella spp. (31.1% K. pneumoniae and 6.7% K. oxytoca), followed by Escherichia coli, (6.7%), Morganella morganii, (2.7%), Citrobacter freundii (1.3%), Proteus mirabilis (1.3%), Providencia stuartii (1.3%), and Serratia spp. (1.3%). These isolates were from five hospitals, 67 (90.5%) from the hospital where the bla <sub>OXA-370</sub> was first described. Sequencing of bla <sub>OXA-48-like</sub> was performed in 52 isolates, including E. cloacae, E. aerogenes, K. pneumoniae, K. oxytoca, E. coli, and C. freundii; all presenting 100% identity with bla <sub>OXA-370</sub>. PFGE revealed the presence of distinct clones among K. pneumoniae, E. cloacae, K. oxytoca, and E. coli. Susceptibility rates to meropenem, imipenem, and ertapenem among OXA-370-producing isolates were 92.3%, 78.8%, 7.7% respectively; the MIC<sub>50</sub> /MIC<sub>90</sub> were 0.38/2 mg/L and 1/3 mg/L for meropenem and imipenem respectively. Overall, antimicrobial susceptibility analysis suggests that OXA-370 lacks carbapenemase activity. Our study demonstrated that the bla <sub>OXA-370</sub> gene is disseminated among several Enterobacteriaceae species and clones, indicating a high potential for dissemination.","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28555403","pmcid":null,"openalex_id":"https://openalex.org/W2618374518","authors":[],"funders":[],"total_grants":0,"fwci":1.141,"citation_percentile":0.72899729,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":3},{"year":2019,"count":4},{"year":2020,"count":5},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"green","license":"other-oa","oa_locations":[{"url":"http://dx.doi.org/10.1007/s10096-017-3012-x","host_type":"repository"},{"url":"http://dx.doi.org/10.1007/s10096-017-3012-x","host_type":"repository"},{"url":"http://link.springer.com/article/10.1007/s10096-017-3012-x/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s10096-017-3012-x.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1007/s10096-017-3012-x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28555403","host_type":"repository"}],"fields_of_study":["Antibiotic Resistance in Bacteria","Pharmaceutical and Antibiotic Environmental Impacts","Enterobacteriaceae and Cronobacter Research"],"mesh_terms":["Carbapenem-Resistant Enterobacteriaceae","beta-Lactamases","Brazil","Genotype","Hospitals","Humans","Microbial Sensitivity Tests","Sequence Analysis, DNA","Molecular Typing","Real-Time Polymerase Chain Reaction"],"keywords":["Citrobacter freundii","Morganella morganii","Ertapenem","Microbiology","Klebsiella pneumoniae","Enterobacter cloacae","Klebsiella oxytoca","Enterobacteriaceae","Biology","Imipenem","Enterobacter aerogenes","Meropenem","Proteus mirabilis","Providencia","Escherichia coli","Gene","Antibiotic resistance","Antibiotics","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T20:15:21.272298Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}