{"doi":"10.1007/s10072-023-07012-3","title":"New approaches to recovery after stroke","abstract":"<jats:title>Abstract</jats:title><jats:p>After a stroke, several mechanisms of neural plasticity can be activated, which may lead to significant recovery. Rehabilitation therapies aim to restore surviving tissue over time and reorganize neural connections. With more patients surviving stroke with varying degrees of neurological impairment, new technologies have emerged as a promising option for better functional outcomes. This review explores restorative therapies based on brain-computer interfaces, robot-assisted and virtual reality, brain stimulation, and cell therapies. Brain-computer interfaces allow for the translation of brain signals into motor patterns. Robot-assisted and virtual reality therapies provide interactive interfaces that simulate real-life situations and physical support to compensate for lost motor function. Brain stimulation can modify the electrical activity of neurons in the affected cortex. Cell therapy may promote regeneration in damaged brain tissue. Taken together, these new approaches could substantially benefit specific deficits such as arm-motor control and cognitive impairment after stroke, and even the chronic phase of recovery, where traditional rehabilitation methods may be limited, and the window for repair is narrow.</jats:p>","journal":"Neurological Sciences","year":2024,"id":651468,"datarank":0.6515708132780527,"base_score":4.343805421853684,"endowment":4.343805421853684,"self_citation_contribution":0.6515708132780527,"citation_network_contribution":0.0,"self_endowment_contribution":0.6515708132780527,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":76,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1699052,"name":"Paula A. Arenas-Vargas","orcid":null,"position":1,"is_corresponding":false},{"id":1699053,"name":"Juan C. Arias-Botero","orcid":null,"position":2,"is_corresponding":false},{"id":1699054,"name":"Manuela Gómez-Vásquez","orcid":null,"position":3,"is_corresponding":false},{"id":1699055,"name":"Manuel F. Jaramillo-López","orcid":null,"position":4,"is_corresponding":false},{"id":1699056,"name":"Jorge M. Gaspar-Toro","orcid":null,"position":5,"is_corresponding":false},{"id":1699051,"name":"Daniel S. Marín-Medina","orcid":"0000-0002-9077-6309","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"New approaches to recovery after stroke","abstract":"<jats:title>Abstract</jats:title><jats:p>After a stroke, several mechanisms of neural plasticity can be activated, which may lead to significant recovery. Rehabilitation therapies aim to restore surviving tissue over time and reorganize neural connections. With more patients surviving stroke with varying degrees of neurological impairment, new technologies have emerged as a promising option for better functional outcomes. This review explores restorative therapies based on brain-computer interfaces, robot-assisted and virtual reality, brain stimulation, and cell therapies. Brain-computer interfaces allow for the translation of brain signals into motor patterns. Robot-assisted and virtual reality therapies provide interactive interfaces that simulate real-life situations and physical support to compensate for lost motor function. Brain stimulation can modify the electrical activity of neurons in the affected cortex. Cell therapy may promote regeneration in damaged brain tissue. Taken together, these new approaches could substantially benefit specific deficits such as arm-motor control and cognitive impairment after stroke, and even the chronic phase of recovery, where traditional rehabilitation methods may be limited, and the window for repair is narrow.</jats:p>","is_dataset_classified":null,"base_score":4.343805421853684,"endowment":4.343805421853684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37697027","pmcid":"PMC10761524","openalex_id":"https://openalex.org/W4386597713","authors":[],"funders":[{"funder_name":"National University of Colombia","grant_id":"","title":null}],"total_grants":1,"fwci":8.3123,"citation_percentile":0.9821278,"influential_citations":0,"citation_trend":[{"year":2023,"count":3},{"year":2024,"count":16},{"year":2025,"count":37},{"year":2026,"count":20}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s10072-023-07012-3.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s10072-023-07012-3.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s10072-023-07012-3/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s10072-023-07012-3","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37697027","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10761524","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10761524/pdf/10072_2023_Article_7012.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10761524","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10761524?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Stroke Rehabilitation and Recovery","Transcranial Magnetic Stimulation Studies","EEG and Brain-Computer Interfaces"],"mesh_terms":["Stroke Rehabilitation","Brain","Cerebral Cortex","Humans","Neuronal Plasticity","Recovery of Function","Stroke"],"keywords":["Rehabilitation","Brain–computer interface","Neuroplasticity","Stroke (engine)","Neurology","Physical medicine and rehabilitation","Neuroscience","Stroke recovery","Brain stimulation","Motor cortex","Medicine","Functional electrical stimulation","Psychology","Electroencephalography","Stimulation","Stroke","Biomedical technology","neuronal plasticity","Stroke Rehabilitation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T09:40:05.957593Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}