{"doi":"10.1007/s10059-009-0098-8","title":"A Mutation of cdc-25.1 Causes Defects in Germ Cells But Not in Somatic Tissues in C. elegans","abstract":null,"journal":"Molecules and Cells","year":2009,"id":597712,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1531336,"name":"Ah-Reum Lee","orcid":null,"position":1,"is_corresponding":false},{"id":1259242,"name":"Ichiro Kawasaki","orcid":"0000-0003-1722-0993","position":2,"is_corresponding":false},{"id":23412,"name":"Susan Strome","orcid":"0000-0001-9496-7412","position":3,"is_corresponding":false},{"id":1531338,"name":"Yhong-Hee Shim","orcid":null,"position":4,"is_corresponding":false},{"id":651719,"name":"Jiyoung Kim","orcid":"0000-0002-2999-3320","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Mutation of cdc-25.1 Causes Defects in Germ Cells But Not in Somatic Tissues in C. elegans","abstract":"By screening C. elegans mutants for severe defects in germline proliferation, we isolated a new loss-of-function allele of cdc-25.1, bn115. bn115 and another previously identified loss-of-function allele nr2036 do not exhibit noticeable cell division defects in the somatic tissues but have reduced numbers of germ cells and are sterile, indicating that cdc-25.1 functions predominantly in the germ line during postembryonic development, and that cdc-25.1 activity is probably not required in somatic lineages during larval development. We analyzed cell division of germ cells and somatic tissues in bn115 homozygotes with germline-specific anti-PGL-1 immunofluorescence and GFP transgenes that express in intestinal cells, in distal tip cells, and in gonadal sheath cells, respectively. We also analyzed the expression pattern of cdc-25.1 with conventional and quantitative RT-PCR. In the presence of three other family members of cdc-25 in C. elegans defects are observed only in the germ line but not in the somatic tissues in cdc-25.1 single mutants, and cdc-25.1 is expressed predominantly, if not exclusively, in the germ line during postembryonic stages. Our findings indicate that the function of cdc-25.1 is unique in the germ line but likely redundant with other members in the soma.","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19533027","pmcid":"PMC2908335","openalex_id":"https://openalex.org/W2000783020","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM034059","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM34059","title":null}],"total_grants":2,"fwci":0.6075,"citation_percentile":0.61103811,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":1},{"year":2014,"count":1},{"year":2016,"count":4},{"year":2017,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2023,"count":1}],"oa_status":"green","license":"http://creativecommons.org/licenses/by-nc-sa/3.0/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2908335","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2908335","host_type":"repository"},{"url":"http://link.springer.com/content/pdf/10.1007/s10059-009-0098-8.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s10059-009-0098-8/fulltext.html","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1016847823110739?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1016847823110739?httpAccept=text/plain","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s10059-009-0098-8","host_type":"publisher"},{"url":"https://doi.org/10.1007/s10059-009-0098-8","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19533027","host_type":"repository"}],"fields_of_study":["Genetics, Aging, and Longevity in Model Organisms","Circadian rhythm and melatonin","Selenium in Biological Systems"],"mesh_terms":["Amino Acid Sequence","Animals","Cell Count","Female","Germ Cells","Immunohistochemistry","Male","Molecular Sequence Data","Mutation","Caenorhabditis elegans","Sequence Homology, Amino Acid","Gene Expression Regulation, Developmental","Reverse Transcriptase Polymerase Chain Reaction","cdc25 Phosphatases","Caenorhabditis elegans Proteins"],"keywords":["Somatic cell","Germline","Biology","Caenorhabditis elegans","Germ cell","Germline mutation","Mutant","Germ","Genetics","Allele","Mutation","Cell biology","Cell division","Molecular biology","Gene","Cell"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"},{"name":"refseq"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T14:01:49.335374Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}