{"doi":"10.1007/s00787-024-02431-9","title":"Exploring latent clusters in pediatric OCD based on symptoms, severity, age, gender, and comorbidity","abstract":"Given diverse symptom expression and high rates of comorbid conditions, the present study explored underlying commonalities among OCD-affected children and adolescents to better conceptualize disorder presentation and associated features. Data from 830 OCD-affected participants presenting to OCD specialty centers was aggregated. Dependent mixture modeling was used to examine latent clusters based on their age- and gender adjusted symptom severity (as measured by the Children's Yale-Brown Obsessive-Compulsive Scale; CY-BOCS), symptom type (as measured by factor scores calculated from the CY-BOCS symptom checklist), and comorbid diagnoses (as assessed via diagnostic interviews). Fit statistics favored a four-cluster model with groups distinguished primarily by symptom expression and comorbidity type. Fit indices for 3-7 cluster models were only marginally different and characteristics of the clusters remained largely stable between solutions with small clusters of distinct presentations added in more complex models. Rather than identifying a single classification system, the findings support the utility of integrating dimensional, developmental, and transdiagnostic information in the conceptualization of OCD-affected children and adolescents. Identified clusters point to the centrality of contamination concerns to OCD, relationships between broader symptom expression and higher levels of comorbidity, and the potential for complex/neurodevelopmental presentations.","journal":"European Child & Adolescent Psychiatry","year":2024,"id":479949,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9342,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1319304,"name":"Robert R. Selles","orcid":"0000-0002-4061-6147","position":1,"is_corresponding":false},{"id":1319305,"name":"Davíð R.M.A. Højgaard","orcid":"0000-0002-6676-2492","position":2,"is_corresponding":false},{"id":390812,"name":"John R. Best","orcid":"0000-0001-5775-7053","position":3,"is_corresponding":false},{"id":1319306,"name":"Karin Melin","orcid":"0000-0002-3297-7735","position":4,"is_corresponding":false},{"id":1319307,"name":"Tord Ivarsson","orcid":"0000-0002-4221-7211","position":5,"is_corresponding":false},{"id":610056,"name":"Per Hove Thomsen","orcid":"0000-0002-4529-4431","position":6,"is_corresponding":false},{"id":1319308,"name":"Bernhard Weidle","orcid":"0000-0002-1822-7671","position":7,"is_corresponding":false},{"id":431593,"name":"Nicole M. McBride","orcid":null,"position":8,"is_corresponding":false},{"id":303752,"name":"Eric A. Storch","orcid":"0000-0002-7631-3703","position":9,"is_corresponding":false},{"id":391166,"name":"Daniel Geller","orcid":"0000-0001-8692-4156","position":10,"is_corresponding":false},{"id":391171,"name":"Sabine Wilhelm","orcid":"0000-0002-5316-2711","position":11,"is_corresponding":false},{"id":1319309,"name":"Lara J. Farrell","orcid":"0000-0002-4231-2227","position":12,"is_corresponding":false},{"id":1016597,"name":"Allison M. Waters","orcid":"0000-0003-2453-793X","position":13,"is_corresponding":false},{"id":1319310,"name":"Sharna Mathieu","orcid":"0000-0003-0784-0638","position":14,"is_corresponding":false},{"id":284043,"name":"Noam Soreni","orcid":"0000-0001-8865-4583","position":15,"is_corresponding":false},{"id":284044,"name":"S. Evelyn Stewart","orcid":"0000-0002-0994-6383","position":16,"is_corresponding":false},{"id":1319311,"name":"Gudmundur Skarphéðinsson","orcid":"0000-0002-8618-153X","position":17,"is_corresponding":false},{"id":1089759,"name":"Orri Smárason","orcid":"0000-0002-8500-024X","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T02:06:58.305365Z","pmid":"38634862","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}