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Specifically, the iron-sulfur cluster biogenesis pathways include several proteins dedicated to the maturation of apoproteins in different cell compartments. Given the complexity of the biogenesis process itself, the iron-sulfur research area constitutes a very challenging and interesting field with still many unaddressed questions. Mutations or malfunctions affecting the iron-sulfur biogenesis machinery have been linked with an increasing amount of disorders such as Friedreich's ataxia and various cardiomyopathies. This review aims to recap the recent discoveries both in the yeast and human iron-sulfur cluster arena, covering recent discoveries from chemistry to disease.","is_dataset_classified":null,"base_score":4.219507705176107,"endowment":4.219507705176107,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29511832","pmcid":"PMC6006200","openalex_id":"https://openalex.org/W2791565546","authors":[],"funders":[{"funder_name":"Royal Society","grant_id":"WM120111","title":null},{"funder_name":"Wellcome Trust","grant_id":"202308/Z16/Z","title":null},{"funder_name":"Wellcome Trust","grant_id":"202308","title":null},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"BB/R009031/1","title":null},{"funder_name":"Wellcome Trust","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Wellcome Trust","grant_id":"","title":null}],"total_grants":6,"fwci":2.0054,"citation_percentile":0.86434416,"influential_citations":0,"citation_trend":[{"year":2018,"count":5},{"year":2019,"count":8},{"year":2020,"count":13},{"year":2021,"count":9},{"year":2022,"count":12},{"year":2023,"count":7},{"year":2024,"count":3},{"year":2025,"count":8},{"year":2026,"count":2}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s00775-018-1548-6.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s00775-018-1548-6.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00775-018-1548-6/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00775-018-1548-6.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00775-018-1548-6","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29511832","host_type":"repository"},{"url":"http://eprints.gla.ac.uk/view/author/38653.html>,","host_type":"journal"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6006200","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6006200","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6006200?pdf=render","host_type":"Europe_PMC"},{"url":"https://link.springer.com/content/pdf/10.1007%2Fs00775-018-1548-6.pdf","host_type":""},{"url":"http://dx.doi.org/10.1007/s00775-018-1548-6","host_type":""},{"url":"https://eprints.gla.ac.uk/158199/1/158199.pdf","host_type":""},{"url":"https://dx.doi.org/10.1007/s00775-018-1548-6","host_type":""}],"fields_of_study":["Metalloenzymes and iron-sulfur proteins","RNA modifications and cancer","Studies on Chitinases and Chitosanases","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Disease","Humans","Iron","Iron-Sulfur Proteins","Mitochondria","Saccharomyces cerevisiae","Oxymonadida"],"keywords":["Biogenesis","Iron–sulfur cluster","Chemistry","Sulfur","Mitochondrion","Cluster (spacecraft)","Biochemistry","Cell biology","Computational biology","Gene","Biology","Enzyme","Cysteine","Metal","Mitochondrial Disease","Iron Regulation","Iron–sulfur","Iron-Sulfur Proteins","Oxymonadida","Iron","Animals","Humans","Disease","Minireview","Saccharomyces cerevisiae","Mitochondria"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T21:03:14.667686Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}