{"doi":"10.1007/s00775-017-1462-3","title":"Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging","abstract":null,"journal":"JBIC Journal of Biological Inorganic Chemistry","year":2017,"id":679112,"datarank":0.5375278407684165,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.0,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1774389,"name":"Feifei Jia","orcid":null,"position":1,"is_corresponding":false},{"id":790966,"name":"Wei Zheng","orcid":"0000-0003-0021-6672","position":2,"is_corresponding":false},{"id":1202595,"name":"Qun Luo","orcid":"0000-0002-7527-460X","position":3,"is_corresponding":false},{"id":1491128,"name":"Yao Zhao","orcid":"0000-0001-9845-8770","position":4,"is_corresponding":false},{"id":1774390,"name":"Fuyi Wang","orcid":null,"position":5,"is_corresponding":false},{"id":449855,"name":"Kui Wu","orcid":"0000-0002-4995-0395","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging","abstract":"Secondary ion mass spectrometry, including nanoscale secondary ion mass spectrometry (NanoSIMS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS), has emerged as a powerful tool for biological imaging, especially for single cell imaging. SIMS imaging can provide information on subcellular distribution of endogenous and exogenous chemicals, including metallodrugs, from membrane through to cytoplasm and nucleus without labeling, and with high spatial resolution and chemical specificity. In this mini-review, we summarize recent progress in the field of SIMS imaging, particularly in the characterization of the subcellular distribution of metallodrugs. We anticipate that the SIMS imaging method will be widely applied to visualize subcellular distributions of drugs and drug candidates in single cells, exerting significant influence on early drug evaluation and metabolism in medicinal and pharmaceutical chemistry. Recent progress of SIMS applications in characterizing the subcellular distributions of metallodrugs was summarized.","is_dataset_classified":null,"base_score":3.58351893845611,"endowment":3.58351893845611,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28508381","pmcid":null,"openalex_id":"https://openalex.org/W2614820090","authors":[],"funders":[{"funder_name":"the 973 Program of MOST","grant_id":"2013CB531805","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"21127901, 21135006, 21505141, 91543101 and 2132100","title":null}],"total_grants":2,"fwci":2.0943,"citation_percentile":0.85034153,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":5},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":7},{"year":2022,"count":6},{"year":2023,"count":3},{"year":2024,"count":4},{"year":2025,"count":5}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/article/10.1007/s00775-017-1462-3/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00775-017-1462-3.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00775-017-1462-3","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28508381","host_type":"repository"}],"fields_of_study":["Ion-surface interactions and analysis","Analytical chemistry methods development","Mass Spectrometry Techniques and Applications","Antineoplastic Agents","Cell Proliferation","Humans","Organometallic Compounds","Single-Cell Analysis","Spectrometry, Mass, Secondary Ion"],"mesh_terms":["Antineoplastic Agents","Humans","Organometallic Compounds","Spectrometry, Mass, Secondary Ion","Cell Proliferation","Single-Cell Analysis"],"keywords":["Chemistry","Mass spectrometry imaging","Secondary ion mass spectrometry","Chemical imaging","Mass spectrometry","Characterization (materials science)","Nanotechnology","Chromatography","Materials science","Single cell","Visualization","Metallodrug"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T12:15:27.867262Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}