{"doi":"10.1007/s007050050178","title":"Molecular characterization of morphologically typical human calicivirus Sapporo","abstract":null,"journal":"Archives of Virology","year":1997,"id":597342,"datarank":0.6496100010429497,"base_score":4.330733340286331,"endowment":4.330733340286331,"self_citation_contribution":0.6496100010429497,"citation_network_contribution":0.0,"self_endowment_contribution":0.6496100010429497,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":75,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1530338,"name":"M. E. Hardy","orcid":null,"position":1,"is_corresponding":false},{"id":1530339,"name":"S. Nakata","orcid":null,"position":2,"is_corresponding":false},{"id":61748,"name":"S. Chiba","orcid":null,"position":3,"is_corresponding":false},{"id":1530340,"name":"M. K. Estes","orcid":null,"position":4,"is_corresponding":false},{"id":1530337,"name":"K. Numata","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Molecular characterization of morphologically typical human calicivirus Sapporo","abstract":"Human calicivirus Sapporo (SV) has typical calicivirus morphology and causes acute gastroenteritis in children. The nucleotide sequence of 3.2 kb of the 3' end of SV was determined from a cloned cDNA. The 3' end of the SV genome is predicted to encode the RNA-dependent RNA polymerase region, the capsid protein and two small open reading frames. The nonstructural and capsid protein coding sequences in the SV genome are fused in a single open reading frame. The organization of these proteins in the SV sequence is similar to that of rabbit hemorrhagic disease virus and the recently described Manchester virus, and distinct from the genome organization of the prototype human calicivirus, Norwalk virus, that lacks typical calicivirus morphology and has been described as a small round structured virus (SRSV). Sequence analysis of the predicted capsid region showed that the SV capsid is longer by approximately 30 amino acids than the capsid of any of the SRSVs, and multiple sequence alignments showed that these additional amino acids are located in the variable region of the capsid protein. Expression of the capsid protein of SV in insect cells resulted in the self-assembly of virus-like particles that have a morphology similar to that of the native virus. This result shows that calicivirus morphology is determined by the primary sequence of the capsid protein.","is_dataset_classified":null,"base_score":4.330733340286331,"endowment":4.330733340286331,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9672617","pmcid":null,"openalex_id":"https://openalex.org/W2072555892","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"AI-38036","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"AI-30448","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"DK-07664","title":null},{"funder_name":"National Institutes of Health","grant_id":"2T32DK007664-31","title":"Research Training in Pediatrics Gastroenterolgy"},{"funder_name":"National Institutes of Health","grant_id":"5T32AI007471-03","title":"RESEARCH TRAINING PROGRAM IN MOLECULAR VIROLOGY"}],"total_grants":5,"fwci":4.2834,"citation_percentile":0.95043702,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2015,"count":3},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s007050050178.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s007050050178/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s007050050178","host_type":"publisher"},{"url":"https://doi.org/10.1007/s007050050178","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9672617","host_type":"repository"},{"url":"https://dx.doi.org/10.1007/s007050050178","host_type":""}],"fields_of_study":["Viral gastroenteritis research and epidemiology","Hepatitis Viruses Studies and Epidemiology","Viral Infections and Immunology Research","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Amino Acid Sequence","Caliciviridae","Capsid","Humans","Infant","Molecular Sequence Data","RNA-Dependent RNA Polymerase","Viral Proteins","Sequence Alignment","Genome, Viral","Caliciviridae Infections","Sequence Homology, Amino Acid"],"keywords":["Calicivirus","Biology","Virology","Feline calicivirus","Caliciviridae","Medical microbiology","Virus","Viral disease","Sequence Homology, Amino Acid","Molecular Sequence Data","Infant","Genome, Viral","RNA-Dependent RNA Polymerase","Viral Proteins","Capsid","Humans","Amino Acid Sequence","Sequence Alignment","Caliciviridae Infections"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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