{"doi":"10.1007/s00705-021-05317-2","title":"Identification of heterogenous nuclear ribonucleoproteins (hnRNPs) and serine- and arginine-rich (SR) proteins that induce human papillomavirus type 16 late gene expression and alter L1 mRNA splicing","abstract":"<jats:title>Abstract</jats:title><jats:p>We have determined the effect of seven serine- and arginine-rich (SR) proteins and 15 heterogenous nuclear ribonucleoproteins (hnRNPs) on human papillomavirus type 16 (HPV16) late gene expression. Of the seven SR proteins analyzed here, SRSF1, SRSF3, and SRSF9 induced HPV16 late gene expression, and five of the SR proteins affected HPV16 L1 mRNA splicing. Of the 15 hnRNP proteins analyzed here, hnRNP A2, hnRNP F, and hnRNP H efficiently induced HPV16 late gene expression, and all of the hnRNPs affected HPV16 L1 mRNA levels or mRNA splicing. Thus, the majority of SR proteins and hnRNPs have the potential to regulate HPV16 L1 mRNA splicing. Strict control of the expression of the immunogenic L1 and L2 capsid proteins may contribute to the ability of HPV16 to cause persistence.</jats:p>","journal":"Archives of Virology","year":2022,"id":34398,"datarank":0.3444656675996454,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.05257914524134838,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.05257914524134838,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":3,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":178220,"name":"Lijing Gong","orcid":null,"position":1,"is_corresponding":false},{"id":178221,"name":"Xiaoxu Cui","orcid":null,"position":2,"is_corresponding":false},{"id":178222,"name":"Johanna Jönsson","orcid":null,"position":3,"is_corresponding":false},{"id":178223,"name":"Yunji Zheng","orcid":null,"position":4,"is_corresponding":false},{"id":166037,"name":"Chengjun Wu","orcid":"0000-0001-9940-2605","position":5,"is_corresponding":false},{"id":178224,"name":"Naoko Kajitani","orcid":null,"position":6,"is_corresponding":false},{"id":178225,"name":"Stefan Schwartz","orcid":"0000-0002-1249-0575","position":7,"is_corresponding":false},{"id":178219,"name":"Chengyu Hao","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34860285","pmcid":"PMC8843915","openalex_id":"https://openalex.org/W3216749441","authors":[],"funders":[{"funder_name":"Cancerfonden","grant_id":"CAN2018/702","title":null},{"funder_name":"Vetenskapsrådet","grant_id":"VR2019-01210","title":null},{"funder_name":"China Scholarship Council","grant_id":"201706170061","title":null},{"funder_name":"China Scholarship Council","grant_id":"201607930006","title":null},{"funder_name":"China Scholarship Council","grant_id":"201809120016","title":null},{"funder_name":"China Scholarship Council","grant_id":"201606525004","title":null},{"funder_name":"Swedish Research Council","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Lund 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Cancer and HPV Research","Cancer-related molecular mechanisms research","Vector-Borne Animal Diseases","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences","Arginine","Gene Expression","Gene Expression Regulation, Viral","Heterogeneous-Nuclear Ribonucleoproteins","Human papillomavirus 16","Humans","RNA, Messenger","Ribonucleoproteins","Serine","Serine-Arginine Splicing Factors"],"mesh_terms":["Serine-Arginine Splicing Factors","Arginine","Humans","Ribonucleoproteins","RNA, Messenger","Serine","Gene Expression","Gene Expression Regulation, Viral","Heterogeneous-Nuclear Ribonucleoproteins","Human papillomavirus 16"],"keywords":["SR protein","Heterogeneous ribonucleoprotein particle","RNA splicing","Biology","Heterogeneous nuclear ribonucleoprotein","Ribonucleoprotein","Gene expression","Messenger RNA","Gene","Alternative splicing","Exonic splicing enhancer","Molecular biology","Cell biology","Genetics","RNA","Gene Expression Regulation, Viral","Human papillomavirus 16","Serine-Arginine Splicing Factors","Brief Report","Arginine","Heterogeneous-Nuclear Ribonucleoproteins","Microbiology in the medical area","Ribonucleoproteins","Mikrobiologi inom det medicinska området","Serine","Humans","RNA, Messenger"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T18:31:00.063886Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}