{"doi":"10.1007/s00702-025-02899-y","title":"Microstructural imaging of brain changes in schizophrenia via quantitative T1 (qT1): a preliminary comparison of two acquisition protocols","abstract":null,"journal":"Journal of Neural Transmission","year":2025,"id":613648,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1581007,"name":"Setare Safara","orcid":null,"position":1,"is_corresponding":false},{"id":1581009,"name":"Kimberly L. Desmond","orcid":null,"position":2,"is_corresponding":false},{"id":386150,"name":"Philip Gerretsen","orcid":"0000-0003-4053-6814","position":3,"is_corresponding":false},{"id":1049058,"name":"Ariel Graff","orcid":null,"position":4,"is_corresponding":false},{"id":352767,"name":"Vincenzo De Luca","orcid":"0000-0002-5421-3584","position":5,"is_corresponding":false},{"id":1581005,"name":"George Nader","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Microstructural imaging of brain changes in schizophrenia via quantitative T1 (qT1): a preliminary comparison of two acquisition protocols","abstract":"Schizophrenia spectrum disorders (SSD) are a complex group of illnesses, and their pathophysiology remains unclear. Recent developments in neuroimaging techniques provided useful quantitative measures, such as quantitative T1 mapping (qT1) that is susceptible to tissue-level, microscopic changes. However, it is important to identify the most sensitive, accurate, and reliable imaging protocol, given the complex nature of SSD. We compared structural brain changes in a pilot sample of 15 SSD patients and 7 healthy controls, cross-sectionally, and using two different qT1 mapping protocols. Our findings showed a global elevation in qT1 values in SSD patients, that was statistically significant in the lateral ventricles, thalamus, caudate, and hippocampus (p < 0.01). Moreover, the two acquisition protocols were differently modulated by demographic factors, such as age, sex, and education, which further illustrates the importance of protocol selection. In conclusion, this investigation revealed microstructural tissue changes in subcortical regions in SSD patients, providing further insights into the pathophysiology of the illness.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40186625","pmcid":null,"openalex_id":"https://openalex.org/W4409191360","authors":[],"funders":[{"funder_name":"Canadian Institutes of Health Research","grant_id":"unidentified","title":"unidentified"}],"total_grants":1,"fwci":1.4053,"citation_percentile":0.78841116,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2025,"count":2}],"oa_status":"closed","license":"Springer Nature TDM","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s00702-025-02899-y.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s00702-025-02899-y/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00702-025-02899-y","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40186625","host_type":"repository"}],"fields_of_study":["Advanced MRI Techniques and Applications","Medical Imaging Techniques and Applications","Advanced Neuroimaging Techniques and Applications","03 medical and health sciences","0302 clinical medicine","Humans","Male","Female","Schizophrenia","Adult","Brain","Middle Aged","Magnetic Resonance Imaging","Pilot Projects","Cross-Sectional Studies","Young Adult"],"mesh_terms":["Adult","Brain","Cross-Sectional Studies","Female","Humans","Magnetic Resonance Imaging","Male","Middle Aged","Pilot Projects","Schizophrenia","Young Adult"],"keywords":["Schizophrenia (object-oriented programming)","Neurology","Neuroscience","Psychology","Neuroimaging","Medicine","Psychiatry","Schizophrenia","Methodology","MRI","Psychosis","Male","Adult","Young Adult","Cross-Sectional Studies","Humans","Brain","Female","Pilot Projects","Middle Aged","Magnetic Resonance Imaging"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T08:48:27.630035Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}