{"doi":"10.1007/s00595-022-02558-9","title":"Microsatellite instability in the high-grade dysplasia component of duodenal adenoma is associated with progression to adenocarcinoma","abstract":null,"journal":"Surgery Today","year":2023,"id":630986,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1634963,"name":"Kouki Ohtsuka","orcid":null,"position":1,"is_corresponding":false},{"id":1634964,"name":"Junji Shibahara","orcid":null,"position":2,"is_corresponding":false},{"id":1634965,"name":"Hirotomo Koda","orcid":null,"position":3,"is_corresponding":false},{"id":595836,"name":"Teppei Morikawa","orcid":"0000-0002-4945-6207","position":4,"is_corresponding":false},{"id":1634966,"name":"Nobutsugu Abe","orcid":null,"position":5,"is_corresponding":false},{"id":471663,"name":"Takashi Watanabe","orcid":"0000-0002-9015-5246","position":6,"is_corresponding":false},{"id":1634967,"name":"Hiroaki Ohnishi","orcid":null,"position":7,"is_corresponding":false},{"id":1634962,"name":"Nobuyoshi Aso","orcid":"0000-0003-4355-0515","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Microsatellite instability in the high-grade dysplasia component of duodenal adenoma is associated with progression to adenocarcinoma","abstract":"<h4>Purpose</h4>We examined the microsatellite instability of duodenal tumors to evaluate their molecular features associated with the adenoma-carcinoma sequence.<h4>Methods</h4>Fifty-two non-ampullary duodenal epithelial tumors collected by endoscopic mucosal resection or surgical resection were studied. When a tumor had two or more dysplasia grades, the highest grade was considered. Representative areas were macro-dissected and subjected to a microsatellite instability analysis and immunohistochemical staining.<h4>Results</h4>The 52 tumors were classified as either adenoma with low-grade dysplasia (n = 18), adenoma with high-grade dysplasia (n = 20), or adenocarcinomas (n = 14). Among these, 3 adenocarcinoma cases showed microsatellite instability and the remaining 49 tumors showed microsatellite stability. Of the 14 adenocarcinoma cases, 3 contained both high-grade dysplasia and adenocarcinoma components, and 11 contained only the adenocarcinoma component. Interestingly, all three adenocarcinoma + high-grade dysplasia cases were microsatellite instability-high in both the adenocarcinoma and high-grade dysplasia components. Immunohistochemical staining of mismatch repair proteins showed mismatch repair deficiency in three microsatellite instability-high adenocarcinoma + high-grade dysplasia cases.<h4>Conclusions</h4>Only adenocarcinoma cases with high-grade dysplasia components were microsatellite instability-high (in both the adenocarcinoma and high-grade dysplasia components). This suggests that microsatellite instability in the high-grade dysplasia component of duodenal adenoma is associated with progression to adenocarcinoma.","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35871406","pmcid":null,"openalex_id":"https://openalex.org/W4286801088","authors":[],"funders":[],"total_grants":0,"fwci":0.545,"citation_percentile":0.62813752,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s00595-022-02558-9.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s00595-022-02558-9/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00595-022-02558-9","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35871406","host_type":"repository"}],"fields_of_study":["Genetic factors in colorectal cancer","Microscopic Colitis","Helicobacter pylori-related gastroenterology studies","Humans","Microsatellite Instability","Duodenal Neoplasms","Adenocarcinoma","Adenoma","Colorectal Neoplasms","Hyperplasia"],"mesh_terms":["Adenocarcinoma","Adenoma","Duodenal Neoplasms","Humans","Hyperplasia","Colorectal Neoplasms","Microsatellite Instability"],"keywords":["Microsatellite instability","Adenocarcinoma","Dysplasia","Adenoma","Medicine","Pathology","Microsatellite","Internal medicine","Cancer","Biology","Genetics","Duodenal Adenocarcinoma","Duodenal Adenoma"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T22:35:21.724847Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}