{"doi":"10.1007/s00592-013-0541-3","title":"DPP-4 inhibitors repress foam cell formation by inhibiting scavenger receptors through protein kinase C pathway","abstract":null,"journal":"Acta Diabetologica","year":2014,"id":598704,"datarank":0.5375278407684165,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.0,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":233130,"name":"Xianwei Wang","orcid":"0000-0002-9603-1324","position":1,"is_corresponding":false},{"id":689321,"name":"Zufeng Ding","orcid":"0000-0001-8643-7059","position":2,"is_corresponding":false},{"id":1534366,"name":"Dongsheng Dai","orcid":null,"position":3,"is_corresponding":false},{"id":276433,"name":"Jawahar L. Mehta","orcid":null,"position":4,"is_corresponding":false},{"id":1183388,"name":"Yao Dai","orcid":"0000-0002-7194-1743","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"DPP-4 inhibitors repress foam cell formation by inhibiting scavenger receptors through protein kinase C pathway","abstract":"Studies show that dipeptidyl peptidase-4 (DPP-4) inhibitors may have an anti-atherosclerotic effect. Since foam cells are key components of atherosclerotic plaque, we studied the effect of DPP-4 inhibitors on foam cell formation. Foam cell formation was studied by treatment of THP-1 macrophages with oxidized low-density lipoprotein in the absence or presence of DPP-4 inhibitors (sitagliptin and NVPDPP728). The expression of scavenger receptors SRA, CD36 and LOX-1 was measured, and their role in foam cell formation in the presence of DPP-4 inhibitors was examined. In additional studies, role of protein kinase C and A in the effect of DPP-4 inhibitors was examined. Foam cell formation was markedly reduced by both DPP-4 inhibitors, as was the expression of CD36 and LOX-1 (CD36 ≫ LOX-1), but not SRA. Simultaneously, there was a reduction in phosphorylated PKC, but not PKA, content. Recovery of phosphorylated PKC following treatment of cells negated the effect of DPP-4 inhibitors on foam cell formation. Further, overexpression of CD36 or LOX-1 blocked the effect of DPP-4 inhibitors on foam cell formation. DPP-4 inhibitors repress foam cell formation through the inhibition of SRs CD36 and LOX-1, most likely via the inhibition of PKC activity. This study provides novel insights into the mechanism of inhibition of atherosclerosis by DPP-4 inhibitors.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24363097","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"BLRD VA","grant_id":"I01 BX000282","title":null}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s00592-013-0541-3.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00592-013-0541-3/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00592-013-0541-3","host_type":"publisher"}],"fields_of_study":["Atherosclerosis","Cell Line","Dipeptidyl Peptidase 4","Dipeptidyl-Peptidase IV Inhibitors","Down-Regulation","Foam Cells","Humans","Lipoproteins, LDL","Macrophages","Protein Kinase C","Pyrazines","Receptors, Scavenger","Sitagliptin Phosphate","Triazoles"],"mesh_terms":["Cell Line","Macrophages","Foam Cells","Humans","Triazoles","Pyrazines","Protein Kinase C","Lipoproteins, LDL","Down-Regulation","Atherosclerosis","Receptors, Scavenger","Dipeptidyl-Peptidase IV Inhibitors","Dipeptidyl Peptidase 4","Sitagliptin Phosphate"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T16:08:45.552969Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}