{"doi":"10.1007/s00508-021-01910-2","title":"An fMRI study of cognitive remediation in drug-naïve subjects diagnosed with first episode schizophrenia","abstract":"<jats:title>Summary</jats:title><jats:sec>\n                <jats:title>Objective</jats:title>\n                <jats:p>The purpose of our functional magnetic resonance imaging (fMRI) study was to examine brain activity using a “1-back” paradigm as working memory task in drug-naïve subjects with first episode schizophrenia before and after cognitive remediation training.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Methods</jats:title>\n                <jats:p>In this study 15 drug-naïve first episode subjects who met DSM-IV criteria for schizophrenia were randomized to receive either atypical antipsychotics (AP, <jats:italic>n</jats:italic> = 8) or atypical antipsychotics in combination with cognitive remediation therapy (AP + CR, <jats:italic>n</jats:italic> = 7), 11 subjects had a follow-up fMRI examination after therapy (AP, <jats:italic>n</jats:italic> = 5; AP + CR, <jats:italic>n</jats:italic> = 6).</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Results</jats:title>\n                <jats:p>In 4 of the 6 AP + CR subjects the number of activation clusters increased, whereas in 4 out of the 5 AP subjects the number of clusters decreased (mean number of clusters: AP + CR = 5.53, SD 12.79, AP = −5.8, SD 6.9).</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Conclusion</jats:title>\n                <jats:p>In this randomized study the number of activation clusters during a working memory task increased after cognitive remediation training. Our data show that neurobiological effects of cognitive remediation can be identified in the very early course of schizophrenia.</jats:p>\n              </jats:sec>","journal":"Wiener klinische Wochenschrift","year":2022,"id":621238,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1604013,"name":"Veronika Schöpf","orcid":null,"position":1,"is_corresponding":false},{"id":1604014,"name":"Andreas Erfurth","orcid":"0000-0003-3870-3521","position":2,"is_corresponding":false},{"id":1384210,"name":"Gabriele Sachs","orcid":"0000-0002-8359-9877","position":3,"is_corresponding":false},{"id":457066,"name":"Julia Furtner","orcid":"0000-0001-8258-3681","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"An fMRI study of cognitive remediation in drug-naïve subjects diagnosed with first episode schizophrenia","abstract":"<jats:title>Summary</jats:title><jats:sec>\n                <jats:title>Objective</jats:title>\n                <jats:p>The purpose of our functional magnetic resonance imaging (fMRI) study was to examine brain activity using a “1-back” paradigm as working memory task in drug-naïve subjects with first episode schizophrenia before and after cognitive remediation training.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Methods</jats:title>\n                <jats:p>In this study 15 drug-naïve first episode subjects who met DSM-IV criteria for schizophrenia were randomized to receive either atypical antipsychotics (AP, <jats:italic>n</jats:italic> = 8) or atypical antipsychotics in combination with cognitive remediation therapy (AP + CR, <jats:italic>n</jats:italic> = 7), 11 subjects had a follow-up fMRI examination after therapy (AP, <jats:italic>n</jats:italic> = 5; AP + CR, <jats:italic>n</jats:italic> = 6).</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Results</jats:title>\n                <jats:p>In 4 of the 6 AP + CR subjects the number of activation clusters increased, whereas in 4 out of the 5 AP subjects the number of clusters decreased (mean number of clusters: AP + CR = 5.53, SD 12.79, AP = −5.8, SD 6.9).</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Conclusion</jats:title>\n                <jats:p>In this randomized study the number of activation clusters during a working memory task increased after cognitive remediation training. Our data show that neurobiological effects of cognitive remediation can be identified in the very early course of schizophrenia.</jats:p>\n              </jats:sec>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34255168","pmcid":"PMC8921014","openalex_id":"https://openalex.org/W3181029327","authors":[],"funders":[{"funder_name":"Medical University of Vienna","grant_id":"","title":null}],"total_grants":1,"fwci":0.883,"citation_percentile":0.70972452,"influential_citations":0,"citation_trend":[{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":3}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s00508-021-01910-2.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s00508-021-01910-2.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s00508-021-01910-2/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00508-021-01910-2","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34255168","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8921014","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8921014","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8921014?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Schizophrenia research and treatment","Cognitive Functions and Memory","Neural and Behavioral Psychology Studies"],"mesh_terms":["Cognitive Remediation","Humans","Magnetic Resonance Imaging","Memory, Short-Term","Schizophrenia","Antipsychotic Agents"],"keywords":["Schizophrenia (object-oriented programming)","Cognitive remediation therapy","Medicine","Working memory","Cognition","Effects of sleep deprivation on cognitive performance","Psychiatry","Clinical psychology","Audiology","Atypical Antipsychotics","Randomized Study","Neuronal Activity","Activation Clusters"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T13:47:28.112075Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}