{"doi":"10.1007/s00441-019-03108-5","title":"Lymphatic vessels in human adipose tissue","abstract":"<jats:title>Abstract</jats:title><jats:p>Despite being considered present in most vascularised tissues, lymphatic vessels have not been properly shown in human adipose tissue (AT). Our goal in this study is to investigate an unanswered question in AT biology, regarding lymphatic network presence in tissue parenchyma. Using human subcutaneous (S-) and visceral (V-) AT samples with whole mount staining for lymphatic specific markers and three-dimensional imaging, we showed lymphatic capillaries and larger lymphatic vessels in the human VAT. Conversely, in the human SAT, microcirculatory lymphatic vascular structures were rarely detected and no initial lymphatics were found.</jats:p>","journal":"Cell and Tissue Research","year":2020,"id":600462,"datarank":0.5101796072493234,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"self_citation_contribution":0.5101796072493234,"citation_network_contribution":0.0,"self_endowment_contribution":0.5101796072493234,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1539477,"name":"Fernanda Gubert","orcid":null,"position":1,"is_corresponding":false},{"id":1539478,"name":"Camila Zaverucha-do-Valle","orcid":null,"position":2,"is_corresponding":false},{"id":1539479,"name":"Tatiana Pereira Pena Dutra","orcid":null,"position":3,"is_corresponding":false},{"id":1539480,"name":"Jackline de Paula Ayres-Silva","orcid":"0000-0003-2225-7723","position":4,"is_corresponding":false},{"id":1539481,"name":"Natasha Fernandes","orcid":null,"position":5,"is_corresponding":false},{"id":1539482,"name":"Antonio Augusto Peixoto de Souza","orcid":null,"position":6,"is_corresponding":false},{"id":1539485,"name":"Marilena Loizidou","orcid":null,"position":7,"is_corresponding":false},{"id":894924,"name":"Christina Maeda Takiya","orcid":"0000-0002-8019-628X","position":8,"is_corresponding":false},{"id":1539489,"name":"Maria Isabel Doria Rossi","orcid":null,"position":9,"is_corresponding":false},{"id":1539490,"name":"Radovan Borojevic","orcid":null,"position":10,"is_corresponding":false},{"id":1539476,"name":"Patricia de Albuquerque Garcia Redondo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Lymphatic vessels in human adipose tissue","abstract":"<jats:title>Abstract</jats:title><jats:p>Despite being considered present in most vascularised tissues, lymphatic vessels have not been properly shown in human adipose tissue (AT). Our goal in this study is to investigate an unanswered question in AT biology, regarding lymphatic network presence in tissue parenchyma. Using human subcutaneous (S-) and visceral (V-) AT samples with whole mount staining for lymphatic specific markers and three-dimensional imaging, we showed lymphatic capillaries and larger lymphatic vessels in the human VAT. Conversely, in the human SAT, microcirculatory lymphatic vascular structures were rarely detected and no initial lymphatics were found.</jats:p>","is_dataset_classified":null,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31776824","pmcid":null,"openalex_id":"https://openalex.org/W2990866476","authors":[],"funders":[],"total_grants":0,"fwci":1.1614,"citation_percentile":0.80613759,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":5},{"year":2022,"count":7},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":5},{"year":2026,"count":6}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s00441-019-03108-5.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s00441-019-03108-5.pdf","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00441-019-03108-5.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00441-019-03108-5/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00441-019-03108-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31776824","host_type":"repository"},{"url":"https://www.arca.fiocruz.br/handle/icict/41471","host_type":"repository"},{"url":"https://arca.fiocruz.br/handle/icict/41471","host_type":"repository"},{"url":"https://discovery.ucl.ac.uk/id/eprint/10088386/","host_type":"repository"}],"fields_of_study":["Lymphatic System and Diseases","Body Contouring and Surgery","Sympathectomy and Hyperhidrosis Treatments","Adipose Tissue","Female","Humans","Imaging, Three-Dimensional","Immunohistochemistry","Intra-Abdominal Fat","Lymphatic Vessels","Male","Middle Aged","Subcutaneous Fat"],"mesh_terms":["Adipose Tissue","Female","Humans","Immunohistochemistry","Male","Middle Aged","Imaging, Three-Dimensional","Lymphatic Vessels","Subcutaneous Fat","Intra-Abdominal Fat"],"keywords":["Lymphatic system","Adipose tissue","Pathology","Lymphatic tissues","Lymphatic vessel","Parenchyma","Lymphatic Endothelium","Biology","Anatomy","Medicine","Cancer","lymphatics","Vessels","Subcutaneous","Visceral","Adipose"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T13:13:16.588571Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}