{"doi":"10.1007/s00441-018-2881-3","title":"Electrical coupling between hippocampal neurons: contrasting roles of principal cell gap junctions and interneuron gap junctions","abstract":null,"journal":"Cell and Tissue Research","year":2018,"id":661159,"datarank":0.5676284450877392,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.0,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":499564,"name":"Miles A. Whittington","orcid":"0000-0002-0247-1362","position":1,"is_corresponding":false},{"id":1725964,"name":"Rafael Gutiérrez","orcid":null,"position":2,"is_corresponding":false},{"id":1286115,"name":"Andreas Draguhn","orcid":"0000-0002-6243-5582","position":3,"is_corresponding":false},{"id":437722,"name":"Roger D. Traub","orcid":"0000-0002-4879-5936","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Electrical coupling between hippocampal neurons: contrasting roles of principal cell gap junctions and interneuron gap junctions","abstract":"There is considerable experimental evidence, anatomical and physiological, that gap junctions exist in the hippocampus. Electrical coupling through these gap junctions may be divided into three types: between principal neurons, between interneurons and at mixed chemical (glutamatergic)/electrical synapses. An approach, combining in vitro experimental with modeling techniques, sheds some light on the functional consequences of electrical coupling, for network oscillations and for seizures. Additionally, in vivo experiments, using mouse connexin knockouts, suggest that the presence of electrical coupling is important for optimal performance on selected behavioral tasks; however, the interpretation of such data, in cellular terms, has so far proven difficult. Given that invertebrate central pattern generators so often depend on both chemical and electrical synapses, our hypothesis is that hippocampus-mediated and -influenced behaviors will act likewise. Experiments, likely hard ones, will be required to test this intuition.","is_dataset_classified":null,"base_score":3.784189633918261,"endowment":3.784189633918261,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30112572","pmcid":null,"openalex_id":"https://openalex.org/W2885176581","authors":[],"funders":[{"funder_name":"CONACYT","grant_id":"Fronteras 1600","title":null},{"funder_name":"BMBF","grant_id":"NeuroCure","title":null},{"funder_name":"DFG","grant_id":"SFB 1134","title":null},{"funder_name":"NIH/NINDS","grant_id":"RO1NS044133","title":null},{"funder_name":"Wellcome Trust","grant_id":"unidentified","title":"unidentified"},{"funder_name":"National Institutes of Health","grant_id":"5R01NS044133-06","title":"Detailed Models of Network Bursts and Oscillations"},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"243553651/SFB 1134","title":"Functional ensembles: Cellular components, patterned activity and plasticity of co-active neurons in local networks"}],"total_grants":7,"fwci":1.4856,"citation_percentile":0.82483105,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":7},{"year":2020,"count":6},{"year":2021,"count":4},{"year":2022,"count":4},{"year":2023,"count":4},{"year":2024,"count":8},{"year":2025,"count":7},{"year":2026,"count":2}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"http://link.springer.com/article/10.1007/s00441-018-2881-3/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00441-018-2881-3.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00441-018-2881-3","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30112572","host_type":"repository"},{"url":"https://dx.doi.org/10.1007/s00441-018-2881-3","host_type":""}],"fields_of_study":["Connexins and lens biology","Neuroscience and Neuropharmacology Research","Neural dynamics and brain function","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Axons","Behavior Observation Techniques","Connexins","Dendrites","Electric Conductivity","Electric Stimulation","Gap Junctions","Hippocampus","Interneurons","Mice","Mice, Knockout","Pyramidal Cells","Rats","Synapses"],"mesh_terms":["Behavior Observation Techniques","Animals","Axons","Dendrites","Electric Conductivity","Electric Stimulation","Hippocampus","Interneurons","Synapses","Gap Junctions","Connexins","Pyramidal Cells","Mice, Knockout","Mice","Rats"],"keywords":["Gap junction","Electrical Synapses","Neuroscience","Glutamatergic","Interneuron","Hippocampal formation","Coupling (piping)","Biology","Connexin","Hippocampus","Nerve net","Electrophysiology","Materials science","Cell biology","Glutamate receptor","Mice, Knockout","Pyramidal Cells","Electric Conductivity","Gap Junctions","Dendrites","Axons","Connexins","Electric Stimulation","Rats","Mice","Interneurons","Synapses","Animals","Behavior Observation Techniques","Axonal coupling","Connexin36","Connexin45","Dendritic coupling","Fast oscillation"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T10:30:55.071738Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}