{"doi":"10.1007/s00441-017-2750-5","title":"Advances in understanding hilar mossy cells of the dentate gyrus","abstract":null,"journal":"Cell and Tissue Research","year":2018,"id":642907,"datarank":0.62147020895873,"base_score":4.143134726391533,"endowment":4.143134726391533,"self_citation_contribution":0.62147020895873,"citation_network_contribution":0.0,"self_endowment_contribution":0.62147020895873,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":62,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":362054,"name":"Helen E. Scharfman","orcid":"0000-0003-4006-3383","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Advances in understanding hilar mossy cells of the dentate gyrus","abstract":"Hilar mossy cells (MCs) of the dentate gyrus (DG) distinguish the DG from other hippocampal subfields (CA1-3) because there are two glutamatergic cell types in the DG rather than one. Thus, in the DG, the main cell types include glutamatergic granule cells (GCs) and MCs, whereas in CA1-3, the only glutamatergic cell type is the pyramidal cell. In contrast to GCs, MCs are different in morphology, intrinsic electrophysiological properties, afferent input and axonal projections, so their function is likely to be very different from GCs. Why are MCs necessary to the DG? In past studies, the answer has been unclear because MCs not only excite GCs directly but also inhibit them disynaptically, by exciting GABAergic neurons that project to GCs. Results of new studies are discussed that shed light on this issue. These studies take advantage of recently available transgenic mice with Cre recombinase expression mostly in MCs and techniques such as optogenetics and DREADDs (designer receptors exclusively activated by designer drugs). The recent studies also address in vivo behavioral functions of MCs. Some of the results support past hypotheses whereas others suggest new conceptualizations of how the MCs contribute to DG circuitry and function. While substantial progess has been made, additional research is still needed to clarify the characteristics and functions of these unique cells.","is_dataset_classified":null,"base_score":4.143134726391533,"endowment":4.143134726391533,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29222692","pmcid":"PMC5993616","openalex_id":"https://openalex.org/W2774235975","authors":[],"funders":[{"funder_name":"NIH","grant_id":"NIH R01 MH-09305, NS-081203, NS-093991","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH109305","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS081203","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R21 NS093991","title":null}],"total_grants":4,"fwci":2.1858,"citation_percentile":0.87758347,"influential_citations":0,"citation_trend":[{"year":2018,"count":4},{"year":2019,"count":10},{"year":2020,"count":6},{"year":2021,"count":15},{"year":2022,"count":8},{"year":2023,"count":7},{"year":2024,"count":3},{"year":2025,"count":8},{"year":2026,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/article/10.1007/s00441-017-2750-5/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00441-017-2750-5.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00441-017-2750-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29222692","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5993616","host_type":"repository"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Memory and Neural Mechanisms","Neurogenesis and neuroplasticity mechanisms","Animals","Behavior","Computer Simulation","Dentate Gyrus","Electrophysiological Phenomena","GABAergic Neurons","Integrases","Mice","Mice, Transgenic","Models, Neurological","Mossy Fibers, Hippocampal","Optogenetics","Rats"],"mesh_terms":["Animals","Behavior","Computer Simulation","Mice, Transgenic","Models, Neurological","Dentate Gyrus","Integrases","Mossy Fibers, Hippocampal","Mice","Rats","Electrophysiological Phenomena","GABAergic Neurons","Optogenetics"],"keywords":["Glutamatergic","Neuroscience","Dentate gyrus","GABAergic","Hippocampal formation","Granule cell","Optogenetics","Biology","Neurogenesis","Glutamate receptor","Receptor","Inhibitory postsynaptic potential","Memory","Hippocampus","Interneuron","Entorhinal Cortex","Ca3","Pattern Separation"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.14609177.v1","title":"Additional file 1 of Causal relationship of CA3 back-projection to the dentate gyrus and its role in CA1 fast ripple generation","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14609177","title":"Additional file 1 of Causal relationship of CA3 back-projection to the dentate gyrus and its role in CA1 fast ripple generation","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T10:45:03.863508Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}