{"doi":"10.1007/s00441-015-2260-2","title":"Klf10 regulates odontoblast differentiation and mineralization via promoting expression of dentin matrix protein 1 and dentin sialophosphoprotein genes","abstract":null,"journal":"Cell and Tissue Research","year":2016,"id":668111,"datarank":0.5244761342199721,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.0,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":56031,"name":"Wentong Li","orcid":null,"position":1,"is_corresponding":false},{"id":668993,"name":"Han Wang","orcid":"0000-0001-5121-3362","position":2,"is_corresponding":false},{"id":1259244,"name":"Chunyan Wan","orcid":"0000-0001-7844-1760","position":3,"is_corresponding":false},{"id":742199,"name":"Daoshu Luo","orcid":"0000-0001-9013-1052","position":4,"is_corresponding":false},{"id":1744658,"name":"Shuli Deng","orcid":null,"position":5,"is_corresponding":false},{"id":1155189,"name":"Hui Chen","orcid":"0000-0002-1633-6348","position":6,"is_corresponding":false},{"id":869904,"name":"Shuo Chen","orcid":"0009-0007-7103-6077","position":7,"is_corresponding":false},{"id":253750,"name":"Zhuo Chen","orcid":"0000-0002-6351-8689","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Klf10 regulates odontoblast differentiation and mineralization via promoting expression of dentin matrix protein 1 and dentin sialophosphoprotein genes","abstract":"Klf10, a member of the Krüppel-like family of transcription factors, is critical for osteoblast differentiation, bone formation and mineralization. However, whether Klf10 is involved in odontoblastic differentiation and tooth development has not been determined. In this study, we investigate the expression patterns of Klf10 during murine tooth development in vivo and its role in odontoblastic differentiation in vitro. Klf10 protein was expressed in the enamel organ and the underlying mesenchyme, ameloblasts and odontoblasts at early and later stages of murine molar formation. Furthermore, the expression of Klf10, Dmp1, Dspp and Runx2 was significantly elevated during the process of mouse dental papilla mesenchymal differentiation and mineralization. The overexpression of Klf10 induced dental papilla mesenchymal cell differentiation and mineralization as detected by alkaline phosphatase staining and alizarin red S assay. Klf10 additionally up-regulated the expression of odontoblastic differentiation marker genes Dmp1, Dspp and Runx2 in mouse dental papilla mesenchymal cells. The molecular mechanism of Klf10 in controlling Dmp1 and Dspp expression is thus to activate their regulatory regions in a dosage-dependent manner. Our results suggest that Klf10 is involved in tooth development and promotes odontoblastic differentiation via the up-regulation of Dmp1 and Dspp transcription.","is_dataset_classified":null,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26310138","pmcid":"PMC5006385","openalex_id":"https://openalex.org/W1940268096","authors":[],"funders":[{"funder_name":"NIDCR NIH HHS","grant_id":"R21 DE019892","title":null},{"funder_name":"NIDCR NIH HHS","grant_id":"R01 DE019802","title":null},{"funder_name":"NIDCR NIH HHS","grant_id":"R01 DE019892","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R21DE019892-02","title":"Development of iPS cells to study craniometaphyseal dysplasia in humans"}],"total_grants":4,"fwci":1.2405,"citation_percentile":0.78350354,"influential_citations":0,"citation_trend":[{"year":2016,"count":2},{"year":2017,"count":5},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":4},{"year":2021,"count":5},{"year":2022,"count":6},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2026,"count":1}],"oa_status":"green","license":"Springer TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5006385","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5006385","host_type":"repository"},{"url":"https://doi.org/10.1007/s00441-015-2260-2","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26310138","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc5006385?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.1007/s00441-015-2260-2","host_type":""}],"fields_of_study":["Kruppel-like factors research","Cancer-related gene regulation","Genetic Syndromes and Imprinting","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Dentin Sialophosphoprotein","Animals","Calcification, Physiologic","Cell Differentiation","Dental Papilla","Humans","Molar","Odontoblasts","Phosphoproteins","RNA, Messenger","Sialoglycoproteins","Biomarkers","Extracellular Matrix Proteins","Gene Expression Regulation, Developmental","Mice","Kruppel-Like Transcription Factors","Early Growth Response Transcription Factors"],"keywords":["Dental papilla","DMP1","Odontoblast","RUNX2","Dentin sialophosphoprotein","Cell biology","Dentinogenesis","Mesenchymal stem cell","Ameloblast","Cellular differentiation","Dental follicle","Osteoblast","Dentin","Chemistry","Biology","Enamel paint","Gene","In vitro","Dentistry","Viral matrix protein","Biochemistry","Medicine","Tooth Development","Dspp","Klf10","Extracellular Matrix Proteins","Odontoblasts","Sialoglycoproteins","Kruppel-Like Transcription Factors","Gene Expression Regulation, Developmental","Cell Differentiation","Phosphoproteins","Molar","Mice","Calcification, Physiologic","Early Growth Response Transcription Factors","Animals","Humans","RNA, Messenger","Biomarkers"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T20:11:37.539356Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}