{"doi":"10.1007/s00441-013-1772-x","title":"Appearance of interstitial cells of Cajal in the human midgut","abstract":null,"journal":"Cell and Tissue Research","year":2014,"id":649751,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1547310,"name":"Goran Radenkovic","orcid":"0000-0001-8974-402X","position":1,"is_corresponding":false},{"id":1693933,"name":"Aleksandra Velickov","orcid":null,"position":2,"is_corresponding":false},{"id":1693932,"name":"Mirjana Abramovic","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Appearance of interstitial cells of Cajal in the human midgut","abstract":"Several subtypes of the interstitial cells of Cajal (ICC) form networks that play a role in gastrointestinal motor control. ICC express c-kit and depend on signaling via Kit receptors for development and phenotype maintenance. At 7-8 weeks of development, c-kit-immunoreactive (c-kit-IR) cells are present in the human oesophagus, stomach and proximal duodenum wall. In the remaining small and large bowel, c-kit-IR cells appear later. The object of the present study is to determine the timing of the appearance of c-kit-IR ICC in the parts of the digestive tube originating from the midgut (distal duodenum, jejunum, ileum and proximal colon). Specimens were obtained from eight human embryos and 11 fetuses at 7-12 weeks of gestational age. The specimens were exposed to anti-c-kit antibodies to investigate ICC differentiation. The differentiation of enteric neurons and smooth muscle cells was immunohistochemically examined by using anti-PGP9,5 and anti-desmin antibodies, respectively. In the distal duodenum, jejunum and ileum, c-kit-IR cells emerged at week 9 at the level of the myenteric plexus in the form of a thin row of cells encircling the inception of the ganglia. These cells were multipolar or spindle-shaped with two long processes and corresponded to the ICC of the myenteric plexus. In the proximal colon, c-kit-IR cells emerged at week 9-10 in the form of two parallel belts of cells extending at the submucosal plexus and the myenteric plexus levels. We conclude that ICC develop following two different patterns in the human midgut.","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24414177","pmcid":null,"openalex_id":"https://openalex.org/W2010814266","authors":[],"funders":[{"funder_name":"Ministry of Education, Science and Technological Development of Republic of Serbia","grant_id":"43012","title":"Monitoring of electromagnetic (EM) radiation from mobile telecommunication systems in living environment, analysis of molecular mechanisms and biomarker defects in the case of chronic exposure, with development of risk estimation models and methods for p"}],"total_grants":1,"fwci":1.4659,"citation_percentile":0.80163913,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":1},{"year":2016,"count":3},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":3},{"year":2022,"count":2},{"year":2025,"count":1}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s00441-013-1772-x.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00441-013-1772-x/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00441-013-1772-x","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00441-013-1772-x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24414177","host_type":"repository"},{"url":"https://dx.doi.org/10.1007/s00441-013-1772-x","host_type":""}],"fields_of_study":["Gastrointestinal motility and disorders","Congenital gastrointestinal and neural anomalies","Infant Health and Development","0301 basic medicine","0303 health sciences","03 medical and health sciences","Desmin","Digestive System","Humans","Immunohistochemistry","Interstitial Cells of Cajal","Proto-Oncogene Proteins c-kit","Ubiquitin Thiolesterase"],"mesh_terms":["Desmin","Digestive System","Humans","Immunohistochemistry","Proto-Oncogene Proteins c-kit","Ubiquitin Thiolesterase","Interstitial Cells of Cajal"],"keywords":["Interstitial cell of Cajal","Myenteric plexus","Duodenum","Enteric nervous system","Jejunum","Submucous plexus","Ileum","Biology","Pathology","Plexus","Anatomy","Gastrointestinal tract","Interstitial cell","Immunohistochemistry","Internal medicine","Medicine","Endocrinology","Proto-Oncogene Proteins c-kit","Humans","Interstitial Cells of Cajal","Digestive System","Ubiquitin Thiolesterase","Desmin"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T04:15:43.291135Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}