{"doi":"10.1007/s00439-008-0583-8","title":"Advances in osteoclast biology resulting from the study of osteopetrotic mutations","abstract":null,"journal":"Human Genetics","year":2009,"id":663697,"datarank":0.7289718606542509,"base_score":4.859812404361672,"endowment":4.859812404361672,"self_citation_contribution":0.7289718606542509,"citation_network_contribution":0.0,"self_endowment_contribution":0.7289718606542509,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":128,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1732882,"name":"A. V. 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Careful analyses of osteopetrosis have provided instrumental information on bone remodeling, including the coupling of bone formation to bone resorption. Based on a range of novel genetic mutations and the resulting osteoclast phenotypes, we discuss how osteopetrosis models have clarified the function of the coupling of bone formation to bone resorption, and the pivotal role of the osteoclast and their function in this phenomenon. We highlight the distinct possibility that osteoclast activities can be divided into two separate avenues: bone resorption and control of bone formation.","is_dataset_classified":null,"base_score":4.859812404361672,"endowment":4.859812404361672,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18987890","pmcid":null,"openalex_id":"https://openalex.org/W1969872849","authors":[],"funders":[],"total_grants":0,"fwci":4.4216,"citation_percentile":0.95237754,"influential_citations":0,"citation_trend":[{"year":2012,"count":10},{"year":2013,"count":13},{"year":2014,"count":13},{"year":2015,"count":6},{"year":2016,"count":5},{"year":2017,"count":8},{"year":2018,"count":7},{"year":2019,"count":4},{"year":2020,"count":7},{"year":2021,"count":3},{"year":2022,"count":4},{"year":2023,"count":6},{"year":2024,"count":2},{"year":2025,"count":3},{"year":2026,"count":3}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s00439-008-0583-8.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00439-008-0583-8/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00439-008-0583-8","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00439-008-0583-8","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18987890","host_type":"repository"}],"fields_of_study":["Bone Metabolism and Diseases","Bone health and treatments","Bone health and osteoporosis research","Adaptor Proteins, Signal Transducing","Animals","Autophagy-Related Proteins","Bone Remodeling","Bone Resorption","Carbonic Anhydrase II","Cathepsin K","Cathepsins","Chloride Channels","Disease Models, Animal","Humans","Membrane Glycoproteins","Membrane Proteins","Mice","Models, Biological","Mutation","Osteoblasts","Osteoclasts","Osteopetrosis","RANK Ligand","Receptor Activator of Nuclear Factor-kappa B","Ubiquitin-Protein Ligases","Vacuolar Proton-Translocating ATPases"],"mesh_terms":["Autophagy-Related Proteins","Animals","Bone Resorption","Cathepsins","Disease Models, Animal","Humans","Membrane Glycoproteins","Membrane Proteins","Models, Biological","Mutation","Osteoblasts","Osteoclasts","Osteopetrosis","Bone Remodeling","Chloride Channels","Carbonic Anhydrase II","Vacuolar Proton-Translocating ATPases","Ubiquitin-Protein Ligases","Adaptor Proteins, Signal Transducing","Mice","RANK Ligand","Receptor Activator of Nuclear Factor-kappa B","Cathepsin K"],"keywords":["Osteopetrosis","Osteoclast","Bone resorption","Biology","Phenotype","Resorption","Bone remodeling period","Bone remodeling","Mutation","Function (biology)","Cell biology","Endocrinology","Genetics","Immunology","In vitro","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T23:10:00.003031Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}