{"doi":"10.1007/s00436-003-0861-2","title":"In vitro trypanocidal activity of dibutyltin dichloride and its fatty acid derivatives","abstract":null,"journal":"Parasitology Research","year":2003,"id":597075,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1529425,"name":"H. Kanbara","orcid":null,"position":1,"is_corresponding":false},{"id":1529426,"name":"T. Yanagi","orcid":null,"position":2,"is_corresponding":false},{"id":1529427,"name":"A. Ichinose","orcid":null,"position":3,"is_corresponding":false},{"id":1529428,"name":"D. A. Ameh","orcid":null,"position":4,"is_corresponding":false},{"id":1529429,"name":"J. J. Bonire","orcid":null,"position":5,"is_corresponding":false},{"id":1529430,"name":"A. J. Nok","orcid":null,"position":6,"is_corresponding":false},{"id":1529424,"name":"M. N. Shuaibu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"In vitro trypanocidal activity of dibutyltin dichloride and its fatty acid derivatives","abstract":"Searching for new compounds against pathogenic trypanosomes has been substantially accelerated by the development of in vitro screening assays. In an attempt to explore the chemotherapeutic potential of organotin compounds and to broaden the search for newer trypanocides, fatty acid derivatives of dibutyltin dichloride were synthesized and their in vitro trypanocidal profiles studied on Trypanosoma brucei brucei, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense. A 24-h time course experiment was conducted with various concentrations of the compounds using a 24-well microtiter plate technique. The compounds tested were trypanocidal in a dose-dependent fashion: inhibiting survival and growth, resulting in irreversible morphological deformation and the eventual death of the parasites. The minimum inhibitory concentrations of the tested diorganotins are at low micromolar ranges: from 0.15-0.75 microM for T. b. brucei, T. b. gambiense and T. b. rhodesiense. These observations suggest that organotin has chemotherapeutic potential.","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12851812","pmcid":null,"openalex_id":"https://openalex.org/W1970209637","authors":[],"funders":[],"total_grants":0,"fwci":0.9441,"citation_percentile":0.69460217,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2017,"count":1},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2025,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s00436-003-0861-2.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00436-003-0861-2/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00436-003-0861-2","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00436-003-0861-2","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12851812","host_type":"repository"}],"fields_of_study":["Organometallic Compounds Synthesis and Characterization","Research on Leishmaniasis Studies","Synthesis and biological activity","Animals","Fatty Acids","Mice","Microscopy, Electron","Microscopy, Electron, Scanning","Organotin Compounds","Parasitic Sensitivity Tests","Trypanocidal Agents","Trypanosoma","Trypanosoma brucei brucei","Trypanosoma brucei gambiense","Trypanosoma brucei rhodesiense"],"mesh_terms":["Animals","Fatty Acids","Microscopy, Electron","Microscopy, Electron, Scanning","Organotin Compounds","Trypanocidal Agents","Trypanosoma","Trypanosoma brucei brucei","Trypanosoma brucei gambiense","Trypanosoma brucei rhodesiense","Parasitic Sensitivity Tests","Mice"],"keywords":["Trypanosoma brucei","Trypanosoma brucei rhodesiense","Biology","In vitro","Trypanocidal agent","Antiparasitic","African trypanosomiasis","Trypanosoma","Fatty acid","Diminazene","Biochemistry","Trypanosomiasis","Virology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T12:09:48.960634Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}