{"doi":"10.1007/s00432-023-04602-8","title":"Common inherited variants of PDCD1, CD274 and HAVCR2 genes differentially modulate the risk and prognosis of adenocarcinoma and squamous cell carcinoma","abstract":"BACKGROUND: To investigate the association between single nucleotide polymorphisms (SNPs) of PDCD1, CD274, and HAVCR2 genes with the risk and outcomes of non-small cell lung cancer (NSCLC) subtypes: squamous cell lung cancer (LUSC) and lung adenocarcinoma (LUAD). METHODS: TaqMan SNP genotyping assays or polymerase chain reaction-restriction fragment length polymorphism methods were used to determine genotypes of: PDCD1: rs36084323, rs7421861, rs11568821, rs2227981, rs10204525; CD274: rs822335, rs10815225, rs17718883, rs2297136, rs4742098, rs4143815; HAVCR2: rs10057302, rs1036199. Among 383 NSCLC patients, 112 were diagnosed with LUAD and 116 with LUSC. The control group consisted of 433 unrelated, cancer-free subjects. RESULTS: A CC genotype of rs4143815 and GG genotype of rs4742098 were associated with two times higher risk of developing LUSC (CC vs. GG + GC, OR = 2.31; 95% CI = 1.32, 4.06; P = 0.003; GG vs. AA + AG, OR = 2.26; 95% CI = 1.17, 4.36; P = 0.016, respectively). Moreover, rs4143815 was an independent predictor of the age at diagnosis of LUAD. The carriers of C allele were diagnosed 4.81 years later (95% CI = 1.47, 8.15; P = 0.006) than patients with the GG genotype. The rs10057302 CA genotype was an independent predictor of overall survival in LUSC (adjusted HR = 0.13; 95% CI = 0.02, 0.93; P = 0.043). NSCLC carriers of rs11568821 T allele had almost double the risk of death (adjusted HR = 2.05; 95% CI = 1.28, 3.29; P = 0.003) compared to carriers of CC genotype. CONCLUSIONS: Our results provided additional evidence that SNPs of genes for PD-1, PD-L1 and TIM-3 differentially modulate the risk and prognosis of LUSC and LUAD.","journal":"Journal of Cancer Research and Clinical Oncology","year":2023,"id":360191,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9673,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1111603,"name":"Marta Wagner","orcid":"0000-0002-2710-2301","position":1,"is_corresponding":false},{"id":1111604,"name":"Konrad Pawełczyk","orcid":"0000-0001-8275-7266","position":2,"is_corresponding":false},{"id":1111605,"name":"Irena Porębska","orcid":"0000-0001-9925-3355","position":3,"is_corresponding":false},{"id":1112072,"name":"Beata Muszczyńska-Bernhard","orcid":null,"position":4,"is_corresponding":false},{"id":1111606,"name":"Aneta Kowal","orcid":"0000-0002-5785-2330","position":5,"is_corresponding":false},{"id":1111607,"name":"Andrzej Wiśniewski","orcid":"0000-0002-1919-2298","position":6,"is_corresponding":false},{"id":1111608,"name":"Monika Kosacka","orcid":"0000-0002-5155-8886","position":7,"is_corresponding":false},{"id":1111609,"name":"Julia Kończak","orcid":"0000-0001-8621-2319","position":8,"is_corresponding":false},{"id":1111610,"name":"Paweł Karpiński","orcid":"0000-0003-3885-694X","position":9,"is_corresponding":false},{"id":1112073,"name":"Dominik Frydryk","orcid":null,"position":10,"is_corresponding":false},{"id":1111611,"name":"Anna Andrzejczak","orcid":"0000-0001-6098-7554","position":11,"is_corresponding":false},{"id":21563,"name":"Lidia Karabon","orcid":"0000-0001-8172-0971","position":12,"is_corresponding":false},{"id":1111612,"name":"Piotr Kuśnierczyk","orcid":"0000-0002-9224-8921","position":13,"is_corresponding":false},{"id":1111613,"name":"Monika Jasek","orcid":"0000-0001-6778-2615","position":14,"is_corresponding":false},{"id":1111602,"name":"Nafeesa Moksud","orcid":"0000-0001-8467-2661","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T01:14:01.896928Z","pmid":"36759392","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}