{"doi":"10.1007/s00430-019-00625-6","title":"HTLV-1-infected asymptomatic carriers compared to HAM/TSP patients over-express the apoptosis- and cytotoxicity-related molecules","abstract":null,"journal":"Medical Microbiology and Immunology","year":2019,"id":656009,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1712411,"name":"Bahare Fazeli","orcid":null,"position":1,"is_corresponding":false},{"id":1712413,"name":"Zohreh Poursina","orcid":null,"position":2,"is_corresponding":false},{"id":1712415,"name":"Farahnaz Tehranian","orcid":null,"position":3,"is_corresponding":false},{"id":1712417,"name":"Veda Vakili","orcid":null,"position":4,"is_corresponding":false},{"id":520493,"name":"Reza Boostani","orcid":"0000-0003-0055-4452","position":5,"is_corresponding":false},{"id":112046,"name":"Houshang Rafatpanah","orcid":null,"position":6,"is_corresponding":false},{"id":1712410,"name":"Asadollah Mohammadi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"HTLV-1-infected asymptomatic carriers compared to HAM/TSP patients over-express the apoptosis- and cytotoxicity-related molecules","abstract":"HTLV-1 infection causes a chronic progressive debilitating neuroinflammatory disease which is called, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). One of the host defense mechanisms against viral infection is apoptosis which may control HTLV-1 infection. Therefore, we aimed to investigate this process and its interaction with viral factors in HTLV-1-infected asymptomatic carriers (ACs) compared to HAM/TSP patients. Fas, FasL, TRAIL, perforin, granzyme A, granzyme B, and granulysin gene expression and serum levels of Fas, FasL, TRAIL, and granulysin in the peripheral blood of 21 sex- and age-matched healthy controls (HCs), ACs, and HAM/TSP patients were evaluated. Also, the level of granulysin secretion in the cell culture supernatant was measured. Finally, the correlation of the expression of these molecules with HTLV-1 proviral load (PVL), Tax, and HBZ mRNA expression was analyzed. ACs compared to HAM/TSP patients significantly over-expressed the Fas, FasL, TRAIL, perforin, and granzyme B molecules. Fas, FasL, TRAIL, and granulysin serum levels were not different among studied groups; whereas, the secretion of granulysin was significantly decreased in ACs and HAM/TSP patients compared to HCs. Also, HAM/TSP patients expressed higher levels of HTLV-1 PVL, Tax, and HBZ mRNA. In addition, in ACs, inverse correlations between the Fas, FasL, TRAIL, perforin, granzyme B, and granulysin levels with HBZ mRNA expression were seen. ACs compared to HAM/TSP patients over-expressed the apoptosis- and cytotoxicity-related molecules. It could be concluded that successful control of the HTLV-1 infection and suppression of HAM/TSP development stem from the strong apoptosis and cytotoxic activity in the peripheral blood of ACs.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31317252","pmcid":null,"openalex_id":"https://openalex.org/W2962707004","authors":[],"funders":[],"total_grants":0,"fwci":0.4569,"citation_percentile":0.59775841,"influential_citations":0,"citation_trend":[{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s00430-019-00625-6.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00430-019-00625-6/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00430-019-00625-6","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31317252","host_type":"repository"}],"fields_of_study":["T-cell and Retrovirus Studies","Animal Disease Management and Epidemiology","Adult","Aged","Apoptosis","Carrier State","Female","Gene Expression Profiling","HTLV-I Infections","Human T-lymphotropic virus 1","Humans","Immunologic Factors","Male","Middle Aged","Plasma","Viral Load"],"mesh_terms":["Adult","Aged","Carrier State","Female","Humans","Immunologic Factors","Male","Middle Aged","Plasma","Human T-lymphotropic virus 1","HTLV-I Infections","Apoptosis","Viral Load","Gene Expression Profiling"],"keywords":["Granulysin","Fas ligand","Perforin","Granzyme B","Granzyme","Tropical spastic paraparesis","Granzyme A","Immunology","Apoptosis","Medicine","Virology","Biology","Immune system","T cell","CD8","Myelopathy","Programmed cell death","Cytotoxicity","Htlv-1","Ham/tsp","Viral Neuroinflammation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T19:36:34.720971Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}