{"doi":"10.1007/s00424-021-02513-6","title":"TRIC-A regulates intracellular Ca2+ homeostasis in cardiomyocytes","abstract":"Abstract Trimeric intracellular cation (TRIC) channels have been identified as monovalent cation channels that are located in the ER/SR membrane. Two isoforms discovered in mammals are TRIC-A (TMEM38a) and TRIC-B (TMEM38b). TRIC-B ubiquitously expresses in all tissues, and TRIC-B −/− mice is lethal at the neonatal stage. TRIC-A mainly expresses in excitable cells. TRIC-A −/− mice survive normally but show abnormal SR Ca 2+ handling in both skeletal and cardiac muscle cells. Importantly, TRIC-A mutations have been identified in human patients with stress-induced arrhythmia. In the past decade, important discoveries have been made to understand the structure and function of TRIC channels, especially its role in regulating intracellular Ca 2+ homeostasis. In this review article, we focus on the potential roles of TRIC-A in regulating cardiac function, particularly its effects on intracellular Ca 2+ signaling of cardiomyocytes and discuss the current knowledge gaps.","journal":"Pflügers Archiv - European Journal of Physiology","year":2021,"id":198178,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9489,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":360582,"name":"Ang Li","orcid":"0000-0002-8784-4702","position":1,"is_corresponding":false},{"id":341621,"name":"Pei‐Hui Lin","orcid":"0000-0002-3894-5099","position":2,"is_corresponding":false},{"id":495367,"name":"Jingsong Zhou","orcid":"0000-0002-5684-7177","position":3,"is_corresponding":false},{"id":341623,"name":"Jianjie Ma","orcid":"0000-0003-3865-6112","position":4,"is_corresponding":false},{"id":649367,"name":"Xinyu Zhou","orcid":"0000-0002-1606-5816","position":0,"is_corresponding":true}],"reference_count":115,"raw_metadata":null,"created_at":"2026-07-18T23:50:27.616568Z","pmid":"33474637","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}