{"doi":"10.1007/s00418-013-1092-y","title":"NF-κB involvement in hyperoxia-induced myocardial damage in newborn rat hearts","abstract":null,"journal":"Histochemistry and Cell Biology","year":2013,"id":600657,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1539970,"name":"Marianna De Colli","orcid":null,"position":1,"is_corresponding":false},{"id":78801,"name":"Monica Rapino","orcid":"0009-0004-8137-3366","position":2,"is_corresponding":false},{"id":1539972,"name":"Valentina Di Valerio","orcid":null,"position":3,"is_corresponding":false},{"id":1539973,"name":"Guya Diletta Marconi","orcid":null,"position":4,"is_corresponding":false},{"id":78799,"name":"Amelia Cataldi","orcid":"0000-0002-4989-6210","position":5,"is_corresponding":false},{"id":1539975,"name":"Veronica Macchi","orcid":null,"position":6,"is_corresponding":false},{"id":1539976,"name":"Raffaele De Caro","orcid":null,"position":7,"is_corresponding":false},{"id":1441938,"name":"Andrea Porzionato","orcid":null,"position":8,"is_corresponding":false},{"id":1539969,"name":"Susi Zara","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"NF-κB involvement in hyperoxia-induced myocardial damage in newborn rat hearts","abstract":"Premature newborns are frequently exposed to hyperoxia ventilation and some literature data indicate the possibility of hyperoxia-induced myocardial damage. Since nuclear factor κB (NF-κB) is a crucial signaling molecule involved in physiological response to hyperoxia in different cell types as well as in various tissues, our attention has been focused on the role played by NF-κB pathway in response to moderate and severe hyperoxia exposure in rat neonatal heart tissue. Akt and IκBα levels, involved in NF-κB activation, along with the balance between apoptotic and survival pathways have also been investigated. Experimental design of the study has involved exposure of newborn rats to room air (controls), 60 % O2 (moderate hyperoxia), or 95 % O2 (severe hyperoxia) for the first two postnatal weeks. Morphological analysis shows a less compact tissue in rat heart exposed to moderate hyperoxia and a decreased number of nuclei in samples exposed to severe hyperoxia. A significant increase of NF-κB positive nuclei percentage and p-IκBα expression in samples exposed to 95 % hyperoxia compared to control and to 60 % hyperoxia is evidenced; in parallel, an increase of pAkt/Akt ratio in both samples exposed to 95 and 60 % hyperoxia is shown. Furthermore, a more evident cytochrome c/Apaf-1 immunocomplex and a decreased Bcl2 expression in 95 % hyperoxia-exposed sample compared to 60 % exposed one is evidenced. In conclusion, our findings suggest the involvement of the NF-κB pathway and Akt signaling in the mechanisms of myocardial hyperoxic damage in the newborns, with particular reference to the induction of oxidative stress-related apoptosis.","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23568329","pmcid":null,"openalex_id":"https://openalex.org/W2042804612","authors":[],"funders":[],"total_grants":0,"fwci":0.605,"citation_percentile":0.68703496,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":5},{"year":2017,"count":1},{"year":2019,"count":2},{"year":2020,"count":3},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s00418-013-1092-y.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00418-013-1092-y/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00418-013-1092-y","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00418-013-1092-y","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23568329","host_type":"repository"},{"url":"http://hdl.handle.net/11577/2659432","host_type":"repository"}],"fields_of_study":["NF-κB Signaling Pathways","Immune Response and Inflammation","Neonatal Respiratory Health Research","Animals","Animals, Newborn","Apoptosis","Disease Models, Animal","Female","Heart","Hyperoxia","Myocardium","NF-kappa B","Oxidative Stress","Proto-Oncogene Proteins c-akt","Rats","Rats, Sprague-Dawley","Signal Transduction"],"mesh_terms":["Animals","Animals, Newborn","Disease Models, Animal","Female","Heart","Myocardium","Signal Transduction","NF-kappa B","Rats, Sprague-Dawley","Apoptosis","Oxidative Stress","Hyperoxia","Proto-Oncogene Proteins c-akt","Rats"],"keywords":["Hyperoxia","Protein kinase B","Apoptosis","Biology","Room air distribution","Andrology","Internal medicine","Endocrinology","Medicine","Lung","Chemistry","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T13:44:52.667143Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}