{"doi":"10.1007/s00418-005-0051-7","title":"E-cadherin in the assessment of aberrant placental cytotrophoblast turnover in pregnancies complicated by pre-eclampsia","abstract":null,"journal":"Histochemistry and Cell Biology","year":2005,"id":648243,"datarank":5.2404750100899395,"base_score":4.564348191467836,"endowment":4.564348191467836,"self_citation_contribution":0.6846522287201755,"citation_network_contribution":4.5558227813697645,"self_endowment_contribution":0.6846522287201755,"citer_contribution":4.5558227813697645,"corpus_percentile":null,"corpus_rank":null,"citation_count":95,"citer_count":92,"citers_with_citation_signal":84,"citers_with_endowment":84,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1689221,"name":"H. A. Lacey","orcid":null,"position":1,"is_corresponding":false},{"id":1689223,"name":"P. N. Baker","orcid":null,"position":2,"is_corresponding":false},{"id":1689224,"name":"I. P. Crocker","orcid":null,"position":3,"is_corresponding":false},{"id":25675,"name":"L. M. Brown","orcid":"0000-0002-5485-7419","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"E-cadherin in the assessment of aberrant placental cytotrophoblast turnover in pregnancies complicated by pre-eclampsia","abstract":"E-cadherin is a cell-cell adhesion protein expressed in cytotrophoblasts, which is lost as they differentiate and syncytialise. We have exploited E-cadherin as a marker of cytotrophoblasts to investigate villous tissue composition in first and third trimester placentae, both in normal pregnancy and pregnancies complicated by pre-eclampsia. We have achieved this by measuring expression levels of E-cadherin at the mRNA level, using Q-PCR, and at the protein level using semi-quantitative Western blotting. We have also combined E-cadherin immunohistochemistry with morphometric analysis of area measurements to define cytotrophoblast and syncytiotrophoblast compartments. This novel use of E-cadherin has revealed a decrease in the proportion of cytotrophoblasts in villous tissue as pregnancy progresses, in the absence of changes in syncytiotrophoblast cover. Moreover, in pre-eclampsia, placental E-cadherin was raised compared to syncytiotrophoblast, suggesting either exaggerated cytotrophoblast proliferation or impaired cytotrophoblast differentiation, both alterations of potential pathogenic importance.","is_dataset_classified":null,"base_score":4.564348191467836,"endowment":4.564348191467836,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16142450","pmcid":null,"openalex_id":"https://openalex.org/W2036739721","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Wellcome Trust","grant_id":"","title":null},{"funder_name":"Wellcome Trust","grant_id":"","title":null}],"total_grants":3,"fwci":3.5315,"citation_percentile":0.91721235,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":4},{"year":2014,"count":5},{"year":2015,"count":4},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2018,"count":7},{"year":2019,"count":5},{"year":2020,"count":5},{"year":2021,"count":7},{"year":2022,"count":11},{"year":2023,"count":2},{"year":2024,"count":4},{"year":2025,"count":4}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s00418-005-0051-7.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00418-005-0051-7/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00418-005-0051-7","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00418-005-0051-7","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16142450","host_type":"repository"},{"url":"https://dx.doi.org/10.1007/s00418-005-0051-7","host_type":""}],"fields_of_study":["Pregnancy and preeclampsia studies","Renal and related cancers","Prenatal Screening and Diagnostics","0301 basic medicine","0303 health sciences","03 medical and health sciences","Adult","Cadherins","Chorionic Villi","Female","Gene Expression Regulation","Humans","Immunohistochemistry","Placenta","Pre-Eclampsia","Pregnancy","Pregnancy Trimester, First","Pregnancy Trimester, Third","RNA, Messenger","Sensitivity and Specificity","Trophoblasts"],"mesh_terms":["Adult","Chorionic Villi","Female","Gene Expression Regulation","Humans","Immunohistochemistry","Placenta","Pre-Eclampsia","Pregnancy","Pregnancy Trimester, First","Pregnancy Trimester, Third","RNA, Messenger","Sensitivity and Specificity","Trophoblasts","Cadherins"],"keywords":["Cytotrophoblast","Syncytiotrophoblast","Placenta","Trophoblast","Biology","Immunohistochemistry","Cadherin","Pregnancy","Andrology","Endocrinology","Internal medicine","Cell biology","Fetus","Cell","Medicine","Genetics","Immunology","Adult","Pregnancy Trimester, Third","Cadherins","Sensitivity and Specificity","Trophoblasts","Pregnancy Trimester, First","Gene Expression Regulation","Pre-Eclampsia","Humans","Female","RNA, Messenger","Chorionic Villi"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T02:24:06.150673Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}