{"doi":"10.1007/s00417-026-07353-7","title":"Associations between psychiatric disorders and medication use, and retinal occlusion: a large-scale retrospective cohort study","abstract":null,"journal":"Graefe's Archive for Clinical and Experimental Ophthalmology","year":2026,"id":658827,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1719878,"name":"Michael Kozlov","orcid":null,"position":1,"is_corresponding":false},{"id":1380688,"name":"Nasiq Hasan","orcid":"0000-0001-6296-8023","position":2,"is_corresponding":false},{"id":1719879,"name":"Shreyaa Rohindra Lall","orcid":null,"position":3,"is_corresponding":false},{"id":393397,"name":"Jay Chhablani","orcid":"0000-0003-1772-3558","position":4,"is_corresponding":false},{"id":1237531,"name":"Elham Sadeghi","orcid":"0000-0003-3802-3219","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Associations between psychiatric disorders and medication use, and retinal occlusion: a large-scale retrospective cohort study","abstract":"<h4>Purpose</h4>To evaluate associations between psychiatric disorders, psychotropic medication use, and retinal vascular occlusion (RAO and RVO) risk using a large real-world database.<h4>Methods</h4>This retrospective cohort study used the TriNetX Research Network (~ 149 million patients). Psychiatric patients were identified via ICD-10 codes and grouped into three cohorts: (1) psychiatric disorders without pharmacologic treatment versus matched healthy controls, (2) medicated versus unmedicated psychiatric patients, and (3) single-class psychotropic medication users versus matched untreated patients. Extensive exclusions minimized confounding. Cohorts were propensity score-matched for demographic and clinical factors. The primary outcome was retinal occlusion within one year of treatment initiation.<h4>Results</h4>Among 3,389,889 matched pairs, psychiatric disorders without medication were not associated with increased RO risk compared with controls (HR 0.97, 95% CI 0.87-1.07, p = 0.49). In contrast, among 2,990,601 matched pairs, psychotropic medication use was associated with a modest increase in RO risk (HR 1.20, 95% CI 1.09-1.33, p < 0.001). Class-specific analyses demonstrated a small but statistically significant association for selective serotonin reuptake inhibitors (SSRIs) (HR 1.17, 95% CI 1.03-1.32, p = 0.013), while no significant associations were observed for other medication classes. Patients who developed RO were older and had a higher burden of vascular comorbidities, including hypertension, diabetes, hyperlipidemia, and obstructive sleep apnea.<h4>Conclusions</h4>Psychiatric disorders alone were not associated with increased RO risk, whereas psychotropic medications, particularly SSRIs, showed a modest increase. Despite low absolute incidence, medication exposure may contribute, warranting cardiovascular risk assessment and ophthalmologic monitoring.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"42371026","pmcid":null,"openalex_id":"https://openalex.org/W7166471146","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.82842908,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.1007/s00417-026-07353-7","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/42371026","host_type":"repository"}],"fields_of_study":["Drug-Induced Ocular Toxicity","Retinal and Optic Conditions","Retinal and Macular Surgery"],"mesh_terms":[],"keywords":["Retrospective cohort study","Cohort study","Retinal","Cohort","MEDLINE","Selective serotonin reuptake inhibitors","Psychiatric disorders","Retinal Vascular Occlusion","Antidepressant","Retinal Vein Occlusion","Retinal Artery Occlusion"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T05:29:40.582276Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}