{"doi":"10.1007/s00415-025-12978-5","title":"Skin α-synuclein assays in diagnosing Parkinson’s disease: a systematic review and meta-analysis","abstract":null,"journal":"Journal of Neurology","year":2025,"id":635495,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1648771,"name":"Mingyue Luan","orcid":null,"position":1,"is_corresponding":false},{"id":756065,"name":"Jing Liu","orcid":"0000-0002-3588-2969","position":2,"is_corresponding":false},{"id":461390,"name":"Qingqing Wang","orcid":"0000-0002-0836-1367","position":3,"is_corresponding":false},{"id":249481,"name":"Jianwen Deng","orcid":"0000-0003-1206-1778","position":4,"is_corresponding":false},{"id":1048782,"name":"Zhaoxia Wang","orcid":"0000-0002-8723-4242","position":5,"is_corresponding":false},{"id":1049299,"name":"Yunchuang Sun","orcid":null,"position":6,"is_corresponding":false},{"id":734183,"name":"Kai Li","orcid":"0000-0003-3140-9688","position":7,"is_corresponding":false},{"id":1129213,"name":"Yang Zhao","orcid":"0009-0008-4044-3785","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Skin α-synuclein assays in diagnosing Parkinson’s disease: a systematic review and meta-analysis","abstract":"<h4>Objective</h4>This systematic review and meta-analysis evaluated the diagnostic performance of skin α-synuclein (α-syn) assays, focusing on key detection techniques.<h4>Methods</h4>A comprehensive search of PubMed, Web of Science, Embase, and Cochrane Library was conducted on April 6, 2024. Bivariate mixed-effects models were used to calculate pooled sensitivity and specificity with 95% confidence intervals (CIs) for each group and subgroup.<h4>Results</h4>In distinguishing Parkinson's disease (PD) from healthy controls (HCs) or non-neurodegenerative controls (NNCs), overall sensitivity and specificity were 0.78 (95% CI 0.75-0.80) and 0.96 (95% CI 0.94-0.97), with seed amplification assays (SAA) showing the highest sensitivity (0.89, 95% CI 0.85-0.93) compared to immunofluorescence (IF) (0.82, 95% CI 0.78-0.85) and immunohistochemistry (IHC) (0.70, 95% CI 0.66-0.74). For differentiating PD from multiple system atrophy (MSA), sensitivity remained high (0.80, 95% CI 0.76-0.83), but specificity was low (0.25, 95% CI 0.20-0.31); SAA, IF and IHC all obtained low pooled specificities (less than 0.3). Discriminating from tauopathies, the pooled sensitivity and specificity were 0.82 (95% CI 0.77-0.86) and 0.88 (95% CI 0.81-0.92), with immunological methods using phosphorylated α-synuclein (p-α-syn) outperforming those using non-phosphorylated α-synuclein (np-α-syn); SAA had a higher sensitivity than immunology techniques.<h4>Interpretation</h4>Skin α-syn assays, particularly SAA and p-α-syn immunological methods, demonstrate strong potential as diagnostic tools for PD; SAA had a higher sensitivity than immunology techniques. However, distinguishing PD from other α-synucleinopathies is still challenging and variability across methods highlight the need for standardization. Further research should focus on integrating skin α-syn detection with other biomarkers to enhance diagnostic precision.","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40205187","pmcid":null,"openalex_id":"https://openalex.org/W4409311059","authors":[],"funders":[{"funder_name":"National Key Research and Development Program of China","grant_id":"2023YFC3605200","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2023YFC3605202","title":null},{"funder_name":"National High Level Hospital Clinical Research Funding","grant_id":"2023IR28","title":null}],"total_grants":3,"fwci":5.7945,"citation_percentile":0.97948099,"influential_citations":0,"citation_trend":[{"year":2025,"count":7},{"year":2026,"count":8}],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s00415-025-12978-5.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s00415-025-12978-5/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00415-025-12978-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40205187","host_type":"repository"}],"fields_of_study":["Parkinson's Disease Mechanisms and Treatments","Neurological disorders and treatments","Voice and Speech Disorders"],"mesh_terms":["Humans","Parkinson Disease","Sensitivity and Specificity","Skin","Biomarkers","alpha-Synuclein"],"keywords":["Parkinson's disease","Neuroradiology","Neurology","Meta-analysis","Medicine","Alpha-synuclein","Synucleinopathies","Disease","Pathology","Psychiatry","α-synuclein","Parkinson’s Disease","Skin Biopsy","Diagnostic Test Accuracy"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T15:11:22.151446Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}