{"doi":"10.1007/s00412-014-0474-9","title":"Functional interplay between cohesin and Smc5/6 complexes","abstract":null,"journal":"Chromosoma","year":2014,"id":595411,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1192298,"name":"Su-Jiun Lin","orcid":null,"position":1,"is_corresponding":false},{"id":742315,"name":"Matthew J. O’Connell","orcid":"0000-0002-0061-2504","position":2,"is_corresponding":false},{"id":446039,"name":"Claudia Tapia-Alveal","orcid":"0000-0002-6778-9822","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Functional interplay between cohesin and Smc5/6 complexes","abstract":"Chromosomes are subjected to massive reengineering as they are replicated, transcribed, repaired, condensed, and segregated into daughter cells. Among the engineers are three large protein complexes collectively known as the structural maintenance of chromosome (SMC) complexes: cohesin, condensin, and Smc5/6. As their names suggest, cohesin controls sister chromatid cohesion, condensin controls chromosome condensation, and while precise functions for Smc5/6 have remained somewhat elusive, most reports have focused on the control of recombinational DNA repair. Here, we focus on cohesin and Smc5/6 function. It is becoming increasingly clear that the functional repertoires of these complexes are greater than sister chromatid cohesion and recombination. These SMC complexes are emerging as interrelated and cooperating factors that control chromosome dynamics throughout interphase. However, they also release their embrace of sister chromatids to enable their segregation at anaphase, resetting the dynamic cycle of SMC-chromosome interactions.","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24981336","pmcid":"PMC4169997","openalex_id":"https://openalex.org/W2117256838","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"GM088162","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM088162","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01GM088162-02","title":"Regulation of chromosome segregation by SMC complexes and Top2 in S. pombe"}],"total_grants":3,"fwci":0.9097,"citation_percentile":0.73425892,"influential_citations":0,"citation_trend":[{"year":2016,"count":5},{"year":2017,"count":2},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"green","license":"Springer TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4169997","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4169997","host_type":"repository"},{"url":"http://link.springer.com/content/pdf/10.1007/s00412-014-0474-9.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00412-014-0474-9/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00412-014-0474-9","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00412-014-0474-9","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24981336","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc4169997?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.1007/s00412-014-0474-9","host_type":""}],"fields_of_study":["Genomics and Chromatin Dynamics","DNA Repair Mechanisms","Chromosomal and Genetic Variations","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Cohesins","Chromosomal Proteins, Non-Histone","Humans","Mitosis","Saccharomyces cerevisiae","Chromosomes, Fungal","Cell Cycle Proteins","Saccharomyces cerevisiae Proteins"],"keywords":["Cohesin","Establishment of sister chromatid cohesion","Separase","Sister chromatids","Condensin","Chromosome segregation","Biology","Chromatid","Anaphase","Cell biology","Genetics","Chromosome","Premature chromosome condensation","Mitosis","Saccharomyces cerevisiae Proteins","Chromosomal Proteins, Non-Histone","Humans","Cell Cycle Proteins","Saccharomyces cerevisiae","Chromosomes, Fungal","Cohesins"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T17:23:59.642287Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}