{"doi":"10.1007/s00380-018-1293-3","title":"Pyruvate dehydrogenase activation precedes the down-regulation of fatty acid oxidation in monocrotaline-induced myocardial toxicity in mice","abstract":null,"journal":"Heart and Vessels","year":2019,"id":603645,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":344067,"name":"Daisuke Shimura","orcid":"0000-0002-9954-2162","position":1,"is_corresponding":false},{"id":1548533,"name":"Ken Uesugi","orcid":null,"position":2,"is_corresponding":false},{"id":1548534,"name":"Ichige Kajimura","orcid":null,"position":3,"is_corresponding":false},{"id":1548535,"name":"Qibin Jiao","orcid":null,"position":4,"is_corresponding":false},{"id":1548536,"name":"Yoichiro Kusakari","orcid":null,"position":5,"is_corresponding":false},{"id":217678,"name":"Tomoyoshi Soga","orcid":null,"position":6,"is_corresponding":false},{"id":1548537,"name":"Nobuhito Goda","orcid":null,"position":7,"is_corresponding":false},{"id":483431,"name":"Susumu Minamisawa","orcid":"0000-0003-4728-2116","position":8,"is_corresponding":false},{"id":1548532,"name":"Gaku Nakai","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Pyruvate dehydrogenase activation precedes the down-regulation of fatty acid oxidation in monocrotaline-induced myocardial toxicity in mice","abstract":"Fatty acid (FA) oxidation is impaired and glycolysis is promoted in the damaged heart. However, the factor(s) in the early stages of myocardial metabolic impairment remain(s) unclear. C57B6 mice were subcutaneously administered monocrotaline (MCT) in doses of 0.3 mg/g body weight twice a week for 3 or 6 weeks. Right and left ventricles at 3 and 6 weeks after administration were subjected to capillary electrophoresis-mass spectrometry metabolomic analysis. We also examined mRNA and protein levels of key metabolic molecules. Although no evidence of PH and right ventricular failure was found in the MCT-administered mice by echocardiographic and histological analyzes, the expression levels of stress markers such as TNFα and IL-6 were increased in right and left ventricles even at 3 weeks, suggesting that there was myocardial damage. Metabolites in the tricarboxylic acid (TCA) cycle were decreased and those in glycolysis were increased at 6 weeks. The expression levels of FA oxidation-related factors were decreased at 6 weeks. The phosphorylation level of pyruvate dehydrogenase (PDH) was significantly decreased at 3 weeks. FA oxidation and the TCA cycle were down-regulated, whereas glycolysis was partially up-regulated by MCT-induced myocardial damage. PDH activation preceded these alterations, suggesting that PDH activation is one of the earliest events to compensate for a subtle metabolic impairment from myocardial damage.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30386918","pmcid":null,"openalex_id":"https://openalex.org/W2899235169","authors":[],"funders":[{"funder_name":"the Ministry of Health, Labor and Welfare of Japan","grant_id":"","title":null},{"funder_name":"Takatomi Research Promotion Funds","grant_id":"","title":null},{"funder_name":"the Ministry of Education, Culture, Sports, Science and Technology of Japan","grant_id":"","title":null},{"funder_name":"the “High-Tech Research Center” Project for Private Universities: MEXT","grant_id":"","title":null},{"funder_name":"the Vehicle Racing Commemorative Foundation","grant_id":"","title":null}],"total_grants":5,"fwci":0.6254,"citation_percentile":0.71859683,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2020,"count":3},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2024,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/article/10.1007/s00380-018-1293-3/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00380-018-1293-3.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00380-018-1293-3","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30386918","host_type":"repository"}],"fields_of_study":["Cardiovascular Function and Risk Factors","Cardiac Ischemia and Reperfusion","Cardiac Imaging and Diagnostics","Animals","Blotting, Western","Cardiomyopathies","Disease Models, Animal","Down-Regulation","Fatty Acids","Heart Ventricles","Male","Mice","Mice, Inbred C57BL","Monocrotaline","Myocardium","Oxidation-Reduction","Pyruvate Dehydrogenase Complex"],"mesh_terms":["Animals","Disease Models, Animal","Fatty Acids","Heart Ventricles","Male","Mice, Inbred C57BL","Cardiomyopathies","Myocardium","Oxidation-Reduction","Pyruvate Dehydrogenase Complex","Blotting, Western","Down-Regulation","Monocrotaline","Mice"],"keywords":["Citric acid cycle","Glycolysis","Pyruvate dehydrogenase complex","Beta oxidation","Internal medicine","Endocrinology","Medicine","Lactate dehydrogenase","Dehydrogenase","Tricarboxylic acid","Metabolism","Biochemistry","Enzyme","Chemistry","Metabolomics","Monocrotaline","Pyruvate Dehydrogenase","Cardiac Metabolism"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T22:25:56.646012Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}