{"doi":"10.1007/s00299-010-0967-9","title":"Metabolic engineering of artemisinin biosynthesis in Artemisia annua L.","abstract":null,"journal":"Plant Cell Reports","year":2011,"id":617994,"datarank":0.6663976884735476,"base_score":4.442651256490317,"endowment":4.442651256490317,"self_citation_contribution":0.6663976884735476,"citation_network_contribution":0.0,"self_endowment_contribution":0.6663976884735476,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":84,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":598781,"name":"Hong Wang","orcid":"0000-0002-0213-3523","position":1,"is_corresponding":false},{"id":1593960,"name":"Zhigao Du","orcid":null,"position":2,"is_corresponding":false},{"id":1593961,"name":"Guofeng Li","orcid":null,"position":3,"is_corresponding":false},{"id":1593962,"name":"Hechun Ye","orcid":null,"position":4,"is_corresponding":false},{"id":1593959,"name":"Benye Liu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Metabolic engineering of artemisinin biosynthesis in Artemisia annua L.","abstract":"Artemisinin, a sesquiterpene lactone isolated from the Chinese medicinal plant Artemisia annua L., is an effective antimalarial agent, especially for multi-drug resistant and cerebral malaria. To date, A. annua is still the only commercial source of artemisinin. The low concentration of artemisinin in A. annua, ranging from 0.01 to 0.8% of the plant dry weight, makes artemisinin relatively expensive and difficult to meet the demand of over 100 million courses of artemisinin-based combinational therapies per year. Since the chemical synthesis of artemisinin is not commercially feasible at present, another promising approach to reduce the price of artemisinin-based antimalarial drugs is metabolic engineering of the plant to obtain a higher content of artemisinin in transgenic plants. In the past decade, we have established an Agrobacterium-mediated transformation system of A. annua, and have successfully transferred a number of genes related to artemisinin biosynthesis into the plant. The various aspects of these efforts are discussed in this review.","is_dataset_classified":null,"base_score":4.442651256490317,"endowment":4.442651256490317,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21184232","pmcid":null,"openalex_id":"https://openalex.org/W2039894471","authors":[],"funders":[],"total_grants":0,"fwci":2.6147,"citation_percentile":0.89876965,"influential_citations":0,"citation_trend":[{"year":2012,"count":9},{"year":2013,"count":10},{"year":2014,"count":8},{"year":2015,"count":7},{"year":2016,"count":11},{"year":2017,"count":6},{"year":2018,"count":4},{"year":2019,"count":2},{"year":2020,"count":3},{"year":2021,"count":4},{"year":2022,"count":5},{"year":2023,"count":5},{"year":2024,"count":1},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s00299-010-0967-9.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00299-010-0967-9/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00299-010-0967-9","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00299-010-0967-9","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21184232","host_type":"repository"}],"fields_of_study":["Plant biochemistry and biosynthesis","Pharmacological Effects of Natural Compounds","Microbial Natural Products and Biosynthesis","Agrobacterium","Antimalarials","Artemisia annua","Artemisinins","Gene Expression Regulation, Plant","Gossypium","Plants, Genetically Modified","Transformation, Genetic"],"mesh_terms":["Antimalarials","Gossypium","Transformation, Genetic","Gene Expression Regulation, Plant","Plants, Genetically Modified","Artemisia annua","Artemisinins","Agrobacterium"],"keywords":["Artemisinin","Artemisia annua","Sesquiterpene lactone","Biology","Metabolic engineering","Malaria","Antimalarial Agent","Biotechnology","Plasmodium falciparum","Traditional medicine","Sesquiterpene","Botany","Biochemistry","Medicine","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T03:09:43.471864Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}