{"doi":"10.1007/s00294-016-0573-7","title":"The repeatability of genome-wide mutation rate and spectrum estimates","abstract":null,"journal":"Current Genetics","year":2016,"id":588552,"datarank":1.1276508696672918,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.6448194959370616,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.6448194959370616,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":22,"citers_with_citation_signal":20,"citers_with_endowment":20,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":258657,"name":"David W. Hall","orcid":"0000-0001-7708-6656","position":1,"is_corresponding":false},{"id":821331,"name":"Megan G. Behringer","orcid":"0000-0001-7036-6014","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The repeatability of genome-wide mutation rate and spectrum estimates","abstract":"Over the last decade, mutation studies have grown in popularity due to the affordability and accessibility of whole genome sequencing. As the number of species in which spontaneous mutation has been directly estimated approaches 20 across two domains of life, questions arise over the repeatability of results in such experiments. Five species were identified in which duplicate mutation studies have been performed. Across these studies the difference in estimated spontaneous mutation rate is at most, weakly significant (p < 0.01). However, a highly significant (p < 10(-5)), threefold difference in the rate of insertions/deletions (indels) exists between two recent studies in Schizosaccharomyces pombe. Upon investigation of the ancestral genome sequence for both studies, a possible anti-mutator allele was identified. The observed variation in indel rate may imply that the use of indel markers, such as microsatellites, for the investigation of genetic diversity within and among populations may be inappropriate because of the assumption of uniform mutation rate within a species.","is_dataset_classified":null,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26919990","pmcid":"PMC4930417","openalex_id":"https://openalex.org/W2291958186","authors":[],"funders":[{"funder_name":"National Institute of General Medical Sciences","grant_id":"R01GM097415","title":null},{"funder_name":"National Institute of General Medical Sciences","grant_id":"T32 GM007103","title":null},{"funder_name":"National Institutes of Health","grant_id":"5T32GM007103-28","title":"GRADUATE TRAINING IN GENETICS"},{"funder_name":"National Institutes of Health","grant_id":"5R01GM097415-04","title":"Sequencing yeast lines to measure rates of neutral and deleterious mutations"}],"total_grants":4,"fwci":3.8243,"citation_percentile":0.9302573,"influential_citations":0,"citation_trend":[{"year":2016,"count":7},{"year":2017,"count":4},{"year":2018,"count":3},{"year":2020,"count":4},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"Springer Nature TDM","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s00294-016-0573-7.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s00294-016-0573-7","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00294-016-0573-7","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00294-016-0573-7","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26919990","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4930417","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc4930417?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.1007/s00294-016-0573-7","host_type":""}],"fields_of_study":["Evolution and Genetic Dynamics","Genomics and Phylogenetic Studies","Genetic diversity and population structure","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Mutation","Yeasts","Reproducibility of Results","Genome, Fungal","Microsatellite Repeats","Evolution, Molecular","Polymorphism, Single Nucleotide","Genomics","INDEL Mutation","Mutation Rate"],"keywords":["Indel","Biology","Mutation rate","Genetics","INDEL Mutation","Mutation","Genome","Microsatellite","Evolutionary biology","Allele","Gene","Single-nucleotide polymorphism","Genotype","Evolution","DNA repair","Yeast","Schizosaccharomyces pombe","Mutation Accumulation","Reproducibility of Results","Genomics","Polymorphism, Single Nucleotide","Evolution, Molecular","Yeasts","Genome, Fungal","Microsatellite Repeats"],"sdg_mappings":[{"sdg_number":7,"sdg_label":"7. Clean energy"},{"sdg_number":13,"sdg_label":"13. Climate action"},{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-21T17:01:22.307524Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}