{"doi":"10.1007/s00280-008-0768-9","title":"Phase I/II trial with docetaxel and S-1 for patients with advanced or recurrent gastric cancer with consideration to age","abstract":null,"journal":"Cancer Chemotherapy and Pharmacology","year":2009,"id":669411,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1748266,"name":"Dae Hyun Yang","orcid":null,"position":1,"is_corresponding":false},{"id":1748267,"name":"Hae Wan Lee","orcid":null,"position":2,"is_corresponding":false},{"id":1748268,"name":"Se Won Hwang","orcid":null,"position":3,"is_corresponding":false},{"id":1748269,"name":"Hun Ho Song","orcid":null,"position":4,"is_corresponding":false},{"id":1748270,"name":"Joo Young Jung","orcid":null,"position":5,"is_corresponding":false},{"id":1538875,"name":"Jung Hye Kwon","orcid":null,"position":6,"is_corresponding":false},{"id":1429711,"name":"Hyo Jung Kim","orcid":"0000-0002-3514-1247","position":7,"is_corresponding":false},{"id":1114574,"name":"Jung Han Kim","orcid":"0000-0001-8264-8772","position":8,"is_corresponding":false},{"id":1748271,"name":"Sa Rah Park","orcid":null,"position":9,"is_corresponding":false},{"id":237390,"name":"Min-Jeong Kim","orcid":"0000-0002-0998-5972","position":10,"is_corresponding":false},{"id":1748272,"name":"Kyung Mi Jang","orcid":null,"position":11,"is_corresponding":false},{"id":1748273,"name":"Choong Kee Park","orcid":null,"position":12,"is_corresponding":false},{"id":1748274,"name":"Jong Hyeok Kim","orcid":null,"position":13,"is_corresponding":false},{"id":1748275,"name":"Bong Hwa Lee","orcid":null,"position":14,"is_corresponding":false},{"id":1876,"name":"Dae Young Zang","orcid":"0000-0002-2602-7848","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Phase I/II trial with docetaxel and S-1 for patients with advanced or recurrent gastric cancer with consideration to age","abstract":"<h4>Purpose</h4>To determine the dose-limiting toxicity (DLT) and activity of combination with docetaxel and S-1 on unresectable gastric cancer.<h4>Patients and methods</h4>Docetaxel was administered intravenously on day 1 and S-1 was administered orally on days 1-14, every 3 weeks. Doses of each drug in phase I study were docetaxel 60-75 mg/m(2) and S-1 60-80 mg/m(2). A phase II study was conducted with the recommended dose (RD) based on phase I.<h4>Results</h4>Sixty-five patients (median age 54 years) were enrolled. The DLTs were neutropenia with fever or stomatitis. The RD was docetaxel 75 mg/m(2) and S-1 60 mg/m(2). Two patients (aged 66 and 64 years) developed septic shock during the initial part of phase II study. A phase I study at lower dose (docetaxel 60 mg/m(2) and S-1 80 mg/m(2)) was conducted for patients older than 60 years, and this dose was determined as the RD for these patients. In the phase II study, frequent grade 3/4 toxicities were neutropenia (47%) and febrile neutropenia (26%). The overall response rate was 50% (95% CI, 35-66%) and median survival was 15.3 months (95% CI, 10.0-20.6 months).<h4>Conclusions</h4>Combination with docetaxel and S-1 was active against advanced gastric cancer and gave manageable toxicities.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18481067","pmcid":null,"openalex_id":"https://openalex.org/W2037572126","authors":[],"funders":[],"total_grants":0,"fwci":0.9798,"citation_percentile":0.7807037,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2015,"count":2},{"year":2016,"count":2},{"year":2024,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s00280-008-0768-9.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00280-008-0768-9/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00280-008-0768-9","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00280-008-0768-9","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18481067","host_type":"repository"}],"fields_of_study":["Gastric Cancer Management and Outcomes","Helicobacter pylori-related gastroenterology studies","Colorectal Cancer Treatments and Studies","Adult","Aged","Antineoplastic Combined Chemotherapy Protocols","Docetaxel","Drug Combinations","Female","Humans","Male","Maximum Tolerated Dose","Middle Aged","Oxonic Acid","Recurrence","Stomach Neoplasms","Taxoids","Tegafur"],"mesh_terms":["Docetaxel","Adult","Aged","Antineoplastic Combined Chemotherapy Protocols","Drug Combinations","Female","Tegafur","Humans","Male","Middle Aged","Oxonic Acid","Recurrence","Stomach Neoplasms","Maximum Tolerated Dose","Taxoids"],"keywords":["Docetaxel","Cancer","Medicine","Oncology","Internal medicine","Clinical trial","Surgery"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-14T18:03:23.303008Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}