{"doi":"10.1007/s00277-025-06378-y","title":"Whole brain radiotherapy combined with CART-cell therapy for relapsed/refractory central nervous system B-cell lymphoma","abstract":null,"journal":"Annals of Hematology","year":2025,"id":629013,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1628881,"name":"Peihao Zheng","orcid":null,"position":1,"is_corresponding":false},{"id":1559255,"name":"Zhonghua Fu","orcid":null,"position":2,"is_corresponding":false},{"id":1628882,"name":"Miaomiao Cao","orcid":null,"position":3,"is_corresponding":false},{"id":1294743,"name":"Fan Yang","orcid":"0000-0003-3671-4745","position":4,"is_corresponding":false},{"id":1628883,"name":"Yuelu Guo","orcid":null,"position":5,"is_corresponding":false},{"id":110431,"name":"Rui Liu","orcid":"0000-0002-5002-7311","position":6,"is_corresponding":false},{"id":1628884,"name":"Lixia Ma","orcid":null,"position":7,"is_corresponding":false},{"id":1628885,"name":"Shaomei Feng","orcid":null,"position":8,"is_corresponding":false},{"id":1628886,"name":"Xiuyan Tao","orcid":null,"position":9,"is_corresponding":false},{"id":1628887,"name":"Biping Deng","orcid":null,"position":10,"is_corresponding":false},{"id":236222,"name":"Yang Lei","orcid":"0000-0002-3572-0345","position":11,"is_corresponding":false},{"id":116586,"name":"Yimeng Dou","orcid":null,"position":12,"is_corresponding":false},{"id":1628888,"name":"Xuenan Zhang","orcid":null,"position":13,"is_corresponding":false},{"id":1585528,"name":"Xiaoyan Ke","orcid":null,"position":14,"is_corresponding":false},{"id":877509,"name":"Kai Hu","orcid":"0000-0002-2900-2961","position":15,"is_corresponding":false},{"id":65937,"name":"Hui Shi","orcid":"0000-0002-2027-723X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Whole brain radiotherapy combined with CART-cell therapy for relapsed/refractory central nervous system B-cell lymphoma","abstract":"Relapsed or refractory central nervous system B-cell lymphoma (r/r CNS-BL), including primary central nervous system lymphoma (PCNSL) and secondary central nervous system lymphoma (SCNSL), remains a significant therapeutic challenge with limited treatment options and poor prognosis. This study investigated the combination of whole-brain radiotherapy (WBRT) and chimeric antigen receptor T-cell (CAR-T) therapy in 27 r/r CNS-BL patients. Peripheral blood mononuclear cells were collected before radiotherapy to prepare CAR-T cells. Patients then received whole-brain radiotherapy (WBRT), with or without local boost, followed by CAR-T cell infusion at least one week after radiotherapy completion. Post-CAR-T therapy, the optimal objective response rate (ORR) increased to 88.9%, and the optimal CR rate reached 85.2%. With a median follow-up of 12 months, the median progression-free survival (PFS) and overall survival (OS) were not reached (NR), and the 1-year estimated PFS and OS rate were 61.3% and 56.6%, respectively. Cytokine release syndrome (CRS) occurred in 48.1% of patients. Immune effector cell-associated neurotoxicity syndrome (ICANS) was observed in 29.6% of patients, with only 3.7% on grade 4, all of whom recovered after treatment. This study demonstrates that the combination of WBRT and CAR-T therapy offers a promising therapeutic strategy for r/r CNS-BL patients, improving remission rates and providing a well-tolerated treatment option.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40278918","pmcid":null,"openalex_id":"https://openalex.org/W4409745611","authors":[],"funders":[],"total_grants":0,"fwci":6.9378,"citation_percentile":0.97329197,"influential_citations":0,"citation_trend":[{"year":2025,"count":5},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s00277-025-06378-y.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s00277-025-06378-y.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s00277-025-06378-y/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00277-025-06378-y","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40278918","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12052746","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12052746/pdf/277_2025_Article_6378.pdf","host_type":"repository"}],"fields_of_study":["CNS Lymphoma Diagnosis and Treatment","CAR-T cell therapy research","Lymphoma Diagnosis and Treatment"],"mesh_terms":["Receptors, Chimeric Antigen","Adult","Aged","Combined Modality Therapy","Female","Humans","Male","Middle Aged","Neoplasm Recurrence, Local","Immunotherapy, Adoptive","Cranial Irradiation","Lymphoma, B-Cell","Central Nervous System Neoplasms"],"keywords":["Cart","Radiation therapy","Hematology","Medicine","Central nervous system","Internal medicine","Lymphoma","Refractory (planetary science)","Oncology","Biology","Whole Brain Radiotherapy","Crs","Central Nervous System Lymphoma","Icans","Cart-cell Therapy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T15:59:13.508396Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}