{"doi":"10.1007/s00277-024-05774-0","title":"Outcomes of patients undergoing third hematopoietic cell transplantation for hematologic malignancies","abstract":null,"journal":"Annals of Hematology","year":2024,"id":620154,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":408862,"name":"Corinne Summers","orcid":"0000-0003-1769-7388","position":1,"is_corresponding":false},{"id":345767,"name":"Filippo Milano","orcid":"0000-0003-3573-2159","position":2,"is_corresponding":false},{"id":397776,"name":"Ann Dahlberg","orcid":"0000-0003-2460-1911","position":3,"is_corresponding":false},{"id":460744,"name":"Marie Bleakley","orcid":"0000-0002-7018-8702","position":4,"is_corresponding":false},{"id":236728,"name":"Brenda M. Sandmaier","orcid":"0000-0002-9767-9739","position":5,"is_corresponding":false},{"id":263446,"name":"Monica S. Thakar","orcid":"0000-0001-5801-5457","position":6,"is_corresponding":false},{"id":1008201,"name":"Emily R. Cox","orcid":"0000-0002-1687-3522","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Outcomes of patients undergoing third hematopoietic cell transplantation for hematologic malignancies","abstract":"With advancements in novel therapeutics, it is unclear whether third hematopoietic cell transplantation (HCT3) has a place in the treatment of recurrent hematopoietic malignancies. We evaluated patients with hematologic malignancies who underwent HCT3 between 2000-2020. Nine patients, with a median age of 18 (9-68) years at HCT3 with acute myelogenous leukemia (n = 5), acute lymphoblastic leukemia (n = 2), myelodysplastic syndrome (n = 1), or undifferentiated acute leukemia (n = 1), were identified. The median time between first HCT and HCT3 was 3.9 (0.7-13.6) years. Indication for HCT3 was relapse (n = 8) or graft failure (n = 1) after second HCT. At HCT3, seven of nine patients were in complete remission by flow cytometry. All experienced robust donor engraftment by one month after HCT3 (≥ 90% CD3) while one died at day + 24 of multi-organ failure and was not evaluable for chimerism. In total, eight patients died from relapse (n = 4), non-relapse, (n = 3) or unknown (n = 1) causes at a median of 0.6 (range, 0.1 - 9.9) years after HCT3. After HCT3, estimated overall survival at 6 months, 1 year, and 5 years was 88%, 63%, and 22%, respectively. In this highly selected group, HCT3 provided a treatment option although long-term survival was still dismal.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39003390","pmcid":"PMC13289596","openalex_id":"https://openalex.org/W4400619386","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"P30 CA015704","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P01 CA078902","title":null},{"funder_name":"National Institutes of Health","grant_id":"2P01CA078902-16","title":"Core C: Administrative Services"},{"funder_name":"National Institutes of Health","grant_id":"3P30CA015704-42S2","title":"Cancer Center Support Grant"}],"total_grants":4,"fwci":0.2983,"citation_percentile":0.57729674,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"green","license":"CC BY NC ND","oa_locations":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13289596/","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13289596/","host_type":"repository"},{"url":"https://link.springer.com/content/pdf/10.1007/s00277-024-05774-0.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s00277-024-05774-0/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00277-024-05774-0","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39003390","host_type":"repository"},{"url":"https://doi.org/10.1016/s2666-6367(21)00164-0","host_type":""},{"url":"https://dx.doi.org/10.1016/s2666-6367(21)00164-0","host_type":""}],"fields_of_study":["Hematopoietic Stem Cell Transplantation","Acute Myeloid Leukemia Research","Acute Lymphoblastic Leukemia research","03 medical and health sciences","0302 clinical medicine","Humans","Adult","Middle Aged","Male","Female","Adolescent","Aged","Hematologic Neoplasms","Child","Young Adult","Treatment Outcome","Survival Rate","Leukemia, Myeloid, Acute","Retrospective Studies"],"mesh_terms":["Adolescent","Adult","Aged","Child","Female","Humans","Male","Middle Aged","Retrospective Studies","Leukemia, Myeloid, Acute","Survival Rate","Treatment Outcome","Hematopoietic Stem Cell Transplantation","Hematologic Neoplasms","Young Adult"],"keywords":["Hematology","Hematopoietic cell","Medicine","Hematologic Neoplasms","Internal medicine","Hematopoietic stem cell transplantation","Transplantation","Oncology","Haematopoiesis","Hematologic malignancy","Intensive care medicine","Stem cell","Biology","Acute leukemia","Hematopoietic Cell Transplantation","Relapsed Leukemia","Post-hematopoietic Cell Transplantation Relapse","Adult","Male","Adolescent","Middle Aged","Survival Rate","Young Adult","Leukemia, Myeloid, Acute","Treatment Outcome","Humans","Female","Child","Aged","Retrospective Studies"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T10:10:08.959159Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}