{"doi":"10.1007/s00259-019-04290-y","title":"Detection of cardiac amyloidosis with 18F-Florbetaben-PET/CT in comparison to echocardiography, cardiac MRI and DPD-scintigraphy","abstract":null,"journal":"European Journal of Nuclear Medicine and Molecular Imaging","year":2019,"id":642072,"datarank":0.7077748306942643,"base_score":4.718498871295094,"endowment":4.718498871295094,"self_citation_contribution":0.7077748306942643,"citation_network_contribution":0.0,"self_endowment_contribution":0.7077748306942643,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":111,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1669811,"name":"Sandra Ihne","orcid":null,"position":1,"is_corresponding":false},{"id":1497082,"name":"Joachim Brumberg","orcid":"0000-0003-0959-4776","position":2,"is_corresponding":false},{"id":1160442,"name":"Caroline Morbach","orcid":"0000-0002-0920-6094","position":3,"is_corresponding":false},{"id":1174807,"name":"Stefan Knop","orcid":"0000-0003-1276-6639","position":4,"is_corresponding":false},{"id":1174806,"name":"K. Martin Kortüm","orcid":"0000-0002-7011-0286","position":5,"is_corresponding":false},{"id":1160441,"name":"Stefan Störk","orcid":"0000-0002-1771-7249","position":6,"is_corresponding":false},{"id":750163,"name":"Andreas K. Buck","orcid":"0000-0002-6447-0613","position":7,"is_corresponding":false},{"id":1669814,"name":"Theresa Reiter","orcid":null,"position":8,"is_corresponding":false},{"id":1669816,"name":"Wolfgang R. Bauer","orcid":null,"position":9,"is_corresponding":false},{"id":344921,"name":"Constantin Lapa","orcid":"0000-0001-7536-2207","position":10,"is_corresponding":false},{"id":1669809,"name":"Malte Kircher","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Detection of cardiac amyloidosis with 18F-Florbetaben-PET/CT in comparison to echocardiography, cardiac MRI and DPD-scintigraphy","abstract":"<h4>Purpose</h4>Cardiac amyloidosis (CA) is a rare cause of heart failure with frequently delayed diagnosis, because specific early signs or symptoms are missing. Recently, direct amyloid imaging using positron emission tomography/computed tomography (PET/CT) has emerged. The aim of this study was to examine the performance of <sup>18</sup>F-florbetaben-PET/CT in detection of CA, and compare it to echocardiography (echo), cardiac MRI (CMR) and scintigraphy. Additionally, the use of <sup>18</sup>F-florbetaben-PET/CT for quantification of amyloid burden and monitoring of treatment response was assessed.<h4>Methods</h4>Twenty-two patients with proven (n = 5) or clinical suspicion (n = 17) of CA underwent <sup>18</sup>F-florbetaben-PET/CT for diagnostic work-up. Qualitative and quantitative assessment including calculation of myocardial tracer retention (MTR) was performed, and compared to echo (n = 20), CMR (n = 16), scintigraphy (n = 16) and serologic biomarkers (NT-proBNP, cTnT, free light chains). In four patients, follow-up PET/CT was available (after treatment initiation, n = 3; surveillance, n = 1).<h4>Results</h4>PET demonstrated myocardial <sup>18</sup>F-florbetaben retention consistent with CA in 14/22 patients. Suspicion of CA was subsequently dropped in all eight PET-negative patients. Amyloid subtypes showed characteristic retention patterns (AL > AA > ATTR; all p < 0.005). MTR correlated with morphologic and functional parameters, as measured by CMR and echo (all r| > 0.47|, all p < 0.05), but not with cardiac biomarkers. Changes in MTR from baseline to follow-up corresponded well to treatment response, as assessed by cardiac biomarkers and performance status.<h4>Conclusions</h4>Imaging of cardiac amyloidosis (CA) with <sup>18</sup>F-florbetaben-PET/CT is feasible and might be useful in differentiating CA subtypes.","is_dataset_classified":null,"base_score":4.718498871295094,"endowment":4.718498871295094,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30798427","pmcid":null,"openalex_id":"https://openalex.org/W2917770534","authors":[],"funders":[],"total_grants":0,"fwci":4.327,"citation_percentile":0.95616725,"influential_citations":0,"citation_trend":[{"year":2019,"count":7},{"year":2020,"count":19},{"year":2021,"count":20},{"year":2022,"count":11},{"year":2023,"count":19},{"year":2024,"count":15},{"year":2025,"count":10},{"year":2026,"count":9}],"oa_status":"bronze","license":"http://www.springer.com/tdm","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s00259-019-04290-y.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.1007/s00259-019-04290-y.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00259-019-04290-y/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00259-019-04290-y.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00259-019-04290-y","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30798427","host_type":"repository"},{"url":"https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/62965","host_type":"repository"}],"fields_of_study":["Amyloidosis: Diagnosis, Treatment, Outcomes","Cardiac Imaging and Diagnostics","Alzheimer's disease research and treatments"],"mesh_terms":["Positron Emission Tomography Computed Tomography","Adult","Aged","Amyloidosis","Aniline Compounds","Echocardiography","Female","Heart","Heart Failure","Humans","Magnetic Resonance Imaging","Male","Middle Aged","Radionuclide Imaging","Stilbenes","Biomarkers","Treatment Outcome","Young Adult"],"keywords":["Medicine","Cardiac amyloidosis","Cardiac PET","Nuclear medicine","Positron emission tomography","Radiology","Cardiac imaging","Amyloidosis","Internal medicine","Heart","Diagnosis","Retention index","Amyloid Imaging","Response Assessment"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T21:28:25.605362Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}