{"doi":"10.1007/s00246-023-03216-8","title":"Cardiac Magnetic Resonance Imaging to Determine Single Ventricle Function in a Pediatric Population is Feasible in a Large Trial Setting: Experience from the Single Ventricle Reconstruction Trial Longitudinal Follow up","abstract":"The Single Ventricle Reconstruction (SVR) Trial was a randomized prospective trial designed to determine survival advantage of the modified Blalock-Taussig-Thomas shunt (BTTS) vs the right ventricle to pulmonary artery conduit (RVPAS) for patients with hypoplastic left heart syndrome. The primary aim of the long-term follow-up (SVRIII) was to determine the impact of shunt type on RV function. In this work, we describe the use of CMR in a large cohort follow up from the SVR Trial as a focused study of single ventricle function. The SVRIII protocol included short axis steady-state free precession imaging to assess single ventricle systolic function and flow quantification. There were 313 eligible SVRIII participants and 237 enrolled, ages ranging from 10 to 12.5 years. 177/237 (75%) participants underwent CMR. The most common reasons for not undergoing CMR exam were requirement for anesthesia (n = 14) or ICD/pacemaker (n = 11). A total of 168/177 (94%) CMR studies were diagnostic for RVEF. Median exam time was 54 [IQR 40-74] minutes, cine function exam time 20 [IQR 14-27] minutes, and flow quantification time 18 [IQR 12-25] minutes. There were 69/177 (39%) studies noted to have intra-thoracic artifacts, most common being susceptibility artifact from intra-thoracic metal. Not all artifacts resulted in non-diagnostic exams. These data describe the use and limitations of CMR for the assessment of cardiac function in a prospective trial setting in a grade-school-aged pediatric population with congenital heart disease. Many of the limitations are expected to decrease with the continued advancement of CMR technology.","journal":"Pediatric Cardiology","year":2023,"id":375086,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9581,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":361274,"name":"Michael D. Taylor","orcid":"0000-0003-0251-8017","position":1,"is_corresponding":false},{"id":932761,"name":"Timothy C. Slesnick","orcid":"0009-0000-6532-9788","position":2,"is_corresponding":false},{"id":891894,"name":"Michael P. DiLorenzo","orcid":"0000-0002-2230-684X","position":3,"is_corresponding":false},{"id":374715,"name":"Anthony M. Hlavacek","orcid":"0000-0002-8281-1522","position":4,"is_corresponding":false},{"id":1137318,"name":"Christopher Z. Lam","orcid":"0000-0002-4605-5600","position":5,"is_corresponding":false},{"id":1137319,"name":"Shagun Sachdeva","orcid":"0000-0003-1919-870X","position":6,"is_corresponding":false},{"id":510568,"name":"Sean M. Lang","orcid":"0000-0002-4804-8789","position":7,"is_corresponding":false},{"id":4233,"name":"Michael J. Campbell","orcid":"0000-0002-5210-9038","position":8,"is_corresponding":false},{"id":1137320,"name":"Jennifer F. Gerardin","orcid":"0000-0002-6911-7499","position":9,"is_corresponding":false},{"id":453180,"name":"Kevin K. Whitehead","orcid":"0000-0001-7343-7949","position":10,"is_corresponding":false},{"id":1094410,"name":"Rahul H. Rathod","orcid":"0000-0002-7149-5421","position":11,"is_corresponding":false},{"id":830241,"name":"Mark Cartoski","orcid":"0000-0003-2762-086X","position":12,"is_corresponding":false},{"id":1005726,"name":"Shaji C. Menon","orcid":"0000-0002-0421-0203","position":13,"is_corresponding":false},{"id":682795,"name":"Felicia Trachtenberg","orcid":null,"position":14,"is_corresponding":false},{"id":953974,"name":"Russell Gongwer","orcid":"0000-0002-9344-9303","position":15,"is_corresponding":false},{"id":54927,"name":"Jane W. Newburger","orcid":"0000-0002-7794-9017","position":16,"is_corresponding":false},{"id":289365,"name":"Caren S. Goldberg","orcid":"0000-0003-3880-2474","position":17,"is_corresponding":false},{"id":734820,"name":"Adam L. Dorfman","orcid":"0000-0002-1229-3774","position":18,"is_corresponding":false},{"id":1137767,"name":"the Pediatric Heart Network Investigators","orcid":null,"position":19,"is_corresponding":false},{"id":411239,"name":"Jon Detterich","orcid":"0000-0002-2086-9569","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T01:16:19.336238Z","pmid":"37405456","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}