{"doi":"10.1007/s002399910015","title":"The Codon-Degeneracy Model of Molecular Evolution","abstract":null,"journal":"Journal of Molecular Evolution","year":2000,"id":609066,"datarank":1.5039606995928851,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.9363322545051459,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.9363322545051459,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":31,"citers_with_citation_signal":29,"citers_with_endowment":29,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1565088,"name":"David A. McClellan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Codon-Degeneracy Model of Molecular Evolution","abstract":"Mitochondrial genetic codons can be categorized by four patterns of nucleotide-site degeneracy based on varying combinations of twofold- or nondegenerate sites at first codon positions and twofold- or fourfold-degenerate sites at third codon positions. Herein, a model of molecular evolution is introduced that uses these patterns to calculate expected substitution frequencies for each codon position and substitution type relative to overall number of synonymous or nonsynonymous substitutions. Regions of the pocket gopher cytochrome oxidase subunit I (COI) and cytochrome b (cyt-b) genes are analyzed using this model. Chi-square distributions are used to produce relative goodness-of-fit (GF) scores for measuring the difference between substitution frequencies predicted by the codon-degeneracy model (CDM), and frequencies inferred using a well-supported phylogenetic tree of closely related species. The GF scores for expected and observed synonymous (GF(syn) = 0.429, p = 0.807) and nonsynonymous (GF(ns) = 2.309, p = 0.679) substitution frequencies resulted in a failure to reject the CDM as a null hypothesis for the molecular evolution of COI and cyt-b in pocket gophers. Alternative tree topologies and calculations of transition bias for these data result in higher GF scores.","is_dataset_classified":null,"base_score":3.784189633918261,"endowment":3.784189633918261,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10684347","pmcid":null,"openalex_id":"https://openalex.org/W1486171446","authors":[],"funders":[],"total_grants":0,"fwci":0.8292,"citation_percentile":0.70407131,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":2},{"year":2015,"count":3},{"year":2016,"count":1},{"year":2020,"count":1},{"year":2021,"count":11},{"year":2022,"count":4},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s002399910015.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s002399910015/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s002399910015","host_type":"publisher"},{"url":"https://doi.org/10.1007/s002399910015","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10684347","host_type":"repository"}],"fields_of_study":["Genomics and Phylogenetic Studies","RNA and protein synthesis mechanisms","Machine Learning in Bioinformatics","Animals","Chi-Square Distribution","Codon","Cytochrome b Group","Electron Transport Complex IV","Evolution, Molecular","Models, Biological","Phylogeny","Rodentia"],"mesh_terms":["Animals","Codon","Cytochrome b Group","Electron Transport Complex IV","Models, Biological","Phylogeny","Rodentia","Chi-Square Distribution","Evolution, Molecular"],"keywords":["Nonsynonymous substitution","Biology","Synonymous substitution","Degeneracy (biology)","Phylogenetic tree","Codon usage bias","Molecular evolution","Genetics","Substitution (logic)","Evolutionary biology","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T02:48:43.502043Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}