{"doi":"10.1007/s00239-016-9765-5","title":"Finding Direction in the Search for Selection","abstract":null,"journal":"Journal of Molecular Evolution","year":2017,"id":595234,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":646247,"name":"Mario dos Reis","orcid":"0000-0001-9514-3976","position":1,"is_corresponding":false},{"id":289015,"name":"Richard A. Goldstein","orcid":"0000-0001-5148-4672","position":2,"is_corresponding":false},{"id":1524124,"name":"Grant Thiltgen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Finding Direction in the Search for Selection","abstract":"Tests for positive selection have mostly been developed to look for diversifying selection where change away from the current amino acid is often favorable. However, in many cases we are interested in directional selection where there is a shift toward specific amino acids, resulting in increased fitness in the species. Recently, a few methods have been developed to detect and characterize directional selection on a molecular level. Using the results of evolutionary simulations as well as HIV drug resistance data as models of directional selection, we compare two such methods with each other, as well as against a standard method for detecting diversifying selection. We find that the method to detect diversifying selection also detects directional selection under certain conditions. One method developed for detecting directional selection is powerful and accurate for a wide range of conditions, while the other can generate an excessive number of false positives.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27913840","pmcid":"PMC5253163","openalex_id":null,"authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"MC_U117573805","title":"Computational modelling of evolutionary change"},{"funder_name":"Medical Research Council","grant_id":"MC_PC_13056","title":null},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"BB/P007562/1","title":null}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"CC BY","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s00239-016-9765-5.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00239-016-9765-5/fulltext.html","host_type":"publisher"},{"url":"https://europepmc.org/articles/PMC5253163","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5253163?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.1007/s00239-016-9765-5","host_type":""},{"url":"https://link.springer.com/content/pdf/10.1007%2Fs00239-016-9765-5.pdf","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/27913840","host_type":""},{"url":"http://dx.doi.org/10.1007/s00239-016-9765-5","host_type":""},{"url":"https://dx.doi.org/10.1007/s00239-016-9765-5","host_type":""},{"url":"https://discovery-pp.ucl.ac.uk/id/eprint/1533963/","host_type":""},{"url":"https://doi.org/https://doi.org/10.1007/s00239-016-9765-5","host_type":""},{"url":"https://doi.org/https://doi.org/10.1007/s00239­016­9765­5","host_type":""}],"fields_of_study":["0301 basic medicine","03 medical and health sciences","0303 health sciences"],"mesh_terms":["Sequence Analysis, Protein","Evolution, Molecular","Phylogeny","Drug Resistance, Viral","Models, Genetic","Computer Simulation","Genetic Variation","Selection, Genetic","Biological Evolution"],"keywords":["Directional selection","Positive Selection","Diversifying Selection","D N/d S","Evolution","Drug Resistance","Evolution, Molecular","Genetic","Models","Sequence Analysis, Protein","Drug Resistance, Viral","Genetics","dN/dS","Computer Simulation","Viral","Selection, Genetic","Selection","Molecular Biology","Ecology, Evolution, Behavior and Systematics","Phylogeny","Models, Genetic","Protein","Molecular","Genetic Variation","Biological Evolution","Original Article","Sequence Analysis"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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