{"doi":"10.1007/s00234-026-03946-5","title":"Peak width of skeletonized mean diffusivity as a quantitative imaging marker of white matter alterations in MRI-negative temporal lobe epilepsy: validation with demographic covariate adjustment","abstract":null,"journal":"Neuroradiology","year":2026,"id":602555,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":428758,"name":"Tingting Zhu","orcid":"0000-0003-3141-1884","position":1,"is_corresponding":false},{"id":461809,"name":"Jing Wang","orcid":"0000-0002-2670-719X","position":2,"is_corresponding":false},{"id":1545356,"name":"Xianhong Lin","orcid":null,"position":3,"is_corresponding":false},{"id":179984,"name":"Xiaotong Wu","orcid":null,"position":4,"is_corresponding":false},{"id":1332296,"name":"Jianjia Zhang","orcid":null,"position":5,"is_corresponding":false},{"id":1545357,"name":"Zhongxing Luo","orcid":null,"position":6,"is_corresponding":false},{"id":1545358,"name":"Yalei Shang","orcid":null,"position":7,"is_corresponding":false},{"id":1010046,"name":"Xiaowei Xu","orcid":"0000-0003-2836-5944","position":8,"is_corresponding":false},{"id":1545354,"name":"Suxiang Jiang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Peak width of skeletonized mean diffusivity as a quantitative imaging marker of white matter alterations in MRI-negative temporal lobe epilepsy: validation with demographic covariate adjustment","abstract":"<h4>Purpose</h4>This study evaluated the peak width of skeletonized mean diffusivity (PSMD) as a quantitative imaging marker in patients with magnetic resonance imaging-negative (MRI-negative) temporal lobe epilepsy (TLE), accounting for age and sex effects.<h4>Methods</h4>This retrospective study included 34 MRI-negative TLE patients and 40 age- and sex-matched healthy controls (HCs). PSMD was calculated using tract-based spatial statistics and histogram analysis. Hierarchical regression identified PSMD determinants. Receiver operating characteristic analysis compared uncorrected and age- and sex-corrected PSMD, with the latter validated by 10-fold cross-validation.<h4>Results</h4>PSMD was significantly elevated in patients versus HCs (2.545 × 10<sup>-</sup>⁴ mm²/s vs. 2.340 × 10<sup>-</sup>⁴ mm²/s, p = 0.004) and independently associated with TLE (OR = 2.39, p = 0.011). Sensitivity analysis confirmed robustness (OR = 2.22, p = 0.013). In addition, males showed higher PSMD than females in both patients (p = 0.022) and HCs (p < 0.001). Furthermore, age (β = 0.453, p = 0.005) and male sex (β = 0.539, p = 0.014) were associated with higher PSMD. Age/sex correction improved specificity (82.5% vs. 67.5%) but reduced sensitivity (64.7% vs. 52.9%), with an area under the curve (AUC) of 0.696. AUC improvement was non-significant (p = 0.676); cross-validated AUC was 0.628.<h4>Conclusion</h4>PSMD is a quantitative marker of diffuse white matter pathology in MRI-negative TLE, modulated by demographic factors. Consistent sex effects across groups indicate biological rather than disease-specific variation. Demographic adjustment improves specificity but not overall accuracy, supporting PSMD for group-level cross-sectional studies. Sex effects must be controlled for in white-matter diffusion MRI.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41724833","pmcid":null,"openalex_id":"https://openalex.org/W7130940739","authors":[],"funders":[{"funder_name":"the China Association Against Epilepsy-Neuroracle EEG Fund","grant_id":"(CB-2022-016).","title":null}],"total_grants":1,"fwci":0.0,"citation_percentile":0.16622985,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1007/s00234-026-03946-5.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1007/s00234-026-03946-5","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00234-026-03946-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41724833","host_type":"repository"}],"fields_of_study":["Epilepsy research and treatment","Advanced Neuroimaging Techniques and Applications","Advanced MRI Techniques and Applications","Humans","Male","Female","Epilepsy, Temporal Lobe","Sensitivity and Specificity","Adult","Reproducibility of Results","White Matter","Retrospective Studies","Diffusion Tensor Imaging","Image Interpretation, Computer-Assisted","Middle Aged"],"mesh_terms":["Adult","Epilepsy, Temporal Lobe","Female","Humans","Image Interpretation, Computer-Assisted","Male","Middle Aged","Retrospective Studies","Sensitivity and Specificity","Reproducibility of Results","Diffusion Tensor Imaging","White Matter"],"keywords":["White matter","Covariate","Neuroradiology","Diffusion MRI","Neuroimaging","Temporal lobe","Neurology","Quantitative assessment","Thermal diffusivity","Temporal lobe epilepsy","Diffusion Tensor Imaging","Peak Width Of Skeletonized Mean Diffusivity","Magnetic Resonance Imaging-negative"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Gender equality"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T19:42:25.787575Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}