{"doi":"10.1007/s00216-006-0964-6","title":"Analysis of the hierarchy of quorum-sensing regulation in Pseudomonas aeruginosa","abstract":null,"journal":"Analytical and Bioanalytical Chemistry","year":2007,"id":659469,"datarank":0.6535063240034389,"base_score":4.356708826689592,"endowment":4.356708826689592,"self_citation_contribution":0.6535063240034389,"citation_network_contribution":0.0,"self_endowment_contribution":0.6535063240034389,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":77,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1721505,"name":"Luen-Luen Li","orcid":null,"position":1,"is_corresponding":false},{"id":1721506,"name":"Vincent M. Isabella","orcid":null,"position":2,"is_corresponding":false},{"id":1721507,"name":"Barbara H. Iglewski","orcid":null,"position":3,"is_corresponding":false},{"id":1721504,"name":"Victoria E. Wagner","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Analysis of the hierarchy of quorum-sensing regulation in Pseudomonas aeruginosa","abstract":"Quorum-sensing in Pseudomonas aeruginosa is known to regulate several aspects of pathogenesis, including virulence factor production, biofilm development, and antimicrobial resistance. Recent high-throughput analysis has revealed the existence of several layers of regulation within the QS-circuit. To address this complexity, mutations in genes encoding known or putative transcriptional regulators that were also identified as being regulated by the las and/or rhl QS systems were screened for their contribution in mediating several phenotypes, for example motility, secreted virulence products, and pathogenic capacity in a lettuce leaf model. These studies have further elucidated the potential contribution to virulence of these genes within the QS regulon.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17139483","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"5T32AI07285","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R37AI37713","title":null},{"funder_name":"National Institutes of Health","grant_id":"5T32AI007285-19","title":"Pre-and Postdoctoral Training Program in Immunology"}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1007/s00216-006-0964-6.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1007/s00216-006-0964-6/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1007/s00216-006-0964-6","host_type":"publisher"},{"url":"https://doi.org/10.1007/s00216-006-0964-6","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/17139483","host_type":""},{"url":"https://dx.doi.org/10.1007/s00216-006-0964-6","host_type":""}],"fields_of_study":["0301 basic medicine","03 medical and health sciences"],"mesh_terms":["Pseudomonas aeruginosa","Transcription Factors","Oligonucleotide Array Sequence Analysis","Virulence","Transcription, Genetic","Gene Expression Regulation, Bacterial","Mutation","Quorum Sensing","Bacterial Physiological Phenomena"],"keywords":["Transcription, Genetic","Virulence","Mutation","Pseudomonas aeruginosa","Quorum Sensing","Gene Expression Regulation, Bacterial","Bacterial Physiological Phenomena","Oligonucleotide Array Sequence Analysis","Transcription Factors"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T06:59:16.406181Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}